2,4-Thiazolidinedione, 5-[[4-[2-(1,3-dioxolan-2-yl)ethoxy]phenyl]methyl]-

Base Information

Chemical Name:2,4-Thiazolidinedione, 5-[[4-[2-(1,3-dioxolan-2-yl)ethoxy]phenyl]methyl]-
CAS No.:298231-55-7
Molecular Formula:C15H17NO5S
Molecular Weight:323.37
Hs Code.:
DSSTox Substance ID:DTXSID40443558
Mol file:298231-55-7.mol

Synonyms:2,4-Thiazolidinedione, 5-[[4-[2-(1,3-dioxolan-2-yl)ethoxy]phenyl]methyl]-;298231-55-7;SCHEMBL7512920;DTXSID40443558;VMPHTPPCAWIZKR-UHFFFAOYSA-N;5-{4-[2-(1,3-dioxolan-2-yl) ethoxy]benzyl}thiazolidine-2,4-dione;5-{4-[2-(1,3-Dioxolan-2-yl)ethoxy]benzyl}thiazolidine-2,4-dione;5-{4-[2-(1,3-Dioxolan-2-yl)ethoxy]benzyl}-thiazolidine-2,4-dione

Suppliers and Price of 2,4-Thiazolidinedione, 5-[[4-[2-(1,3-dioxolan-2-yl)ethoxy]phenyl]methyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,4-Thiazolidinedione, 5-[[4-[2-(1,3-dioxolan-2-yl)ethoxy]phenyl]methyl]-

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:323.08274382
Heavy Atom Count:22
Complexity:405

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COC(O1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3

Technology Process of 2,4-Thiazolidinedione, 5-[[4-[2-(1,3-dioxolan-2-yl)ethoxy]phenyl]methyl]-

There total 1 articles about 2,4-Thiazolidinedione, 5-[[4-[2-(1,3-dioxolan-2-yl)ethoxy]phenyl]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 18742-02-4
2-bromo-2-(2-ethyl)dioxolane

: 74772-78-4
5-(4-hydroxybenzyl)-2,4-thiazolidinedione

: 298231-55-7
5-{4-[2-(1,3-dioxolan-2-yl)ethoxy]benzyl}thiazolidine-2,4-dione

Guidance literature:: 5-(4-hydroxybenzyl)-2,4-thiazolidinedione; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

2-bromo-2-(2-ethyl)dioxolane; In N,N-dimethyl-formamide; at 50 ℃; for 5h; Further stages.;
DOI:10.1021/jm990522t

Reference yield: 40.0%

: 298231-55-7
5-{4-[2-(1,3-dioxolan-2-yl)ethoxy]benzyl}thiazolidine-2,4-dione

: 172648-47-4
5-[4-(3-oxopropoxy)benzyl]thiazolidine-2,4-dione

Guidance literature:: With acetic acid; at 60 ℃; for 4h;
DOI:10.1021/jm990522t

Reference yield:

: 298231-55-7
5-{4-[2-(1,3-dioxolan-2-yl)ethoxy]benzyl}thiazolidine-2,4-dione

: 5-{4-[2-(3-Methyl-3H-imidazo[4,5-b]pyridin-2-yl)ethoxyl]-benzyl}thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: 40 percent / aq. AcOH / 4 h / 60 °C

2.1: AcOH / ethanol / 4 h / 20 °C

2.2: 3 percent / I₂ / 1,2-dimethoxy-ethane / 24 h / 60 °C

With acetic acid; In ethanol; 1.1: Acidolysis / 2.1: Cyclization / 2.2: Oxidation;
DOI:10.1021/jm990522t