Bis-(tert-butyl) ((4-bromophenyl)methyl)phosphonate

Base Information

Chemical Name:Bis-(tert-butyl) ((4-bromophenyl)methyl)phosphonate
CAS No.:300583-37-3
Molecular Formula:C15H24BrO3P
Molecular Weight:363.232
Hs Code.:
DSSTox Substance ID:DTXSID20464584
Nikkaji Number:J1.471.338G
Wikidata:Q82289968
Mol file:300583-37-3.mol

Synonyms:300583-37-3;Bis-(tert-butyl) ((4-bromophenyl)methyl)phosphonate;SCHEMBL4958625;DTXSID20464584;HSZRXHSJWXZFFC-UHFFFAOYSA-N

Suppliers and Price of Bis-(tert-butyl) ((4-bromophenyl)methyl)phosphonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Bis-(tert-butyl) ((4-bromophenyl)methyl)phosphonate

Chemical Property:

PSA：45.34000
LogP:5.77240
XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:362.06464
Heavy Atom Count:20
Complexity:329

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OP(=O)(CC1=CC=C(C=C1)Br)OC(C)(C)C

Technology Process of Bis-(tert-butyl) ((4-bromophenyl)methyl)phosphonate

There total 2 articles about Bis-(tert-butyl) ((4-bromophenyl)methyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 13086-84-5
di-tert-butyl phosphite

: 589-15-1
1-bromomethyl-4-bromobenzene

: 300583-37-3
[(4-bromophenyl)methyl]-phosphonoic acid bis(tert-butyl) ester

Guidance literature:: di-tert-butyl phosphite; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

1-bromomethyl-4-bromobenzene; In tetrahydrofuran; for 20h; Further stages.; Heating;
DOI:10.1016/j.bmcl.2007.11.056

Reference yield: 91.0%

: 13086-84-5
di-tert-butyl phosphite

: 589-15-1
1-bromomethyl-4-bromobenzene

: 300583-37-3
[(4-bromophenyl)methyl]-phosphonoic acid bis(tert-butyl) ester

Guidance literature:: di-tert-butyl phosphite; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃;

1-bromomethyl-4-bromobenzene; In tetrahydrofuran; at 0 - 20 ℃; Further stages.;
DOI:10.1021/ol0157609

Reference yield: 95.0%

: 300583-37-3
[(4-bromophenyl)methyl]-phosphonoic acid bis(tert-butyl) ester

: 1009641-03-5
4-[di-(tert-butyl)phosphonomethyl]phenyl boronic acid

Guidance literature:: [(4-bromophenyl)methyl]-phosphonoic acid bis(tert-butyl) ester; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

With Trimethyl borate; In tetrahydrofuran; for 0.5h; Further stages.;
DOI:10.1016/j.bmcl.2007.11.056