2-QUINOXALINECARBALDEHYDE

Base Information

• Chemical Name: 2-QUINOXALINECARBALDEHYDE
• CAS No.: 1593-08-4
• Molecular Formula: C9H6N2O
• Molecular Weight: 158.159
• Hs Code.: 29339900
• Mol file: 1593-08-4.mol

Synonyms:2-Formylquinoxaline;Quinoxalin-2-carboxaldehyde;

Chemical Property of 2-QUINOXALINECARBALDEHYDE

Chemical Property:

• Vapor Pressure: 0.000331mmHg at 25°C
• Melting Point: 107-111°C
• Refractive Index: 1.7
• Boiling Point: 319.783 °C at 760 mmHg
• PKA: -0.15±0.30(Predicted)
• Flash Point: 151.632 °C
• PSA: 42.85000
• Density: 1.3 g/cm³
• LogP: 1.44230
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%min ^*data from raw suppliers

2-Quinoxalinecarboxaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 20/21/22-36/38-36/37/38-22
• Safety Statements: 26-36/37/39-22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A 2-substituted quinoxaline derivative used in the preparation of stabilized hemiacetals with a wide range of cosmetic uses. As 2-substituted quinoxaline derivative, 2-Quinoxalinecarbaldehyde can be used in the the preparation of stabilized hemiacetals with a wide range of cosmetic uses.

Technology Process of 2-QUINOXALINECARBALDEHYDE

There total 23 articles about 2-QUINOXALINECARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-methylquinoxaline (7251-61-8) → Quinoxaline-2-carboxaldehyde (1593-08-4)

Guidance literature:

With tert.-butylhydroperoxide; selenium(IV) oxide; In 1,4-dioxane; at 50 ℃; for 1.5h;

DOI:10.3987/com-02-9702

Reference yield: 94.0%

2-quinoxalinecarboxaldehyde dimethylacetal (434318-22-6) → Quinoxaline-2-carboxaldehyde (1593-08-4)

Guidance literature:

With formic acid; water; at 20 ℃;

DOI:10.1002/ejoc.200801050

Reference yield: 92.0%

2,2-dihydroxy-1,3-propanedial (4464-20-4) + 1,2-diamino-benzene (95-54-5) → Quinoxaline-2-carboxaldehyde (1593-08-4)

Guidance literature:

In ethanol; at 60 - 70 ℃; for 4h;

DOI:10.1002/ejoc.200801050

upstream raw materials:

2-methylquinoxaline

quinoxaline-2-carbaldehyde-diethylacetal

(1R,2S,3R)-1-(quinoxalin-2-yl)butane-1,2,3,4-tetraol

1,3,5-Trioxan

Downstream raw materials:

2-quinoxalinecarboxaldehyde benzylhydrazone

(E)-3-phenyl-1-(quinoxalin-2-yl)prop-2-en-1-one

4-(quinoxalin-2-ylmethyl-amino)-benzoic acid ethyl ester

C₁₆H₁₁N₅O₃

Refernces

• 1、 Wong, John W.,Watson Jr., Harry A.,Bouressa, James F.,Burns, Michael P.,Cawley, James J.,Doro, Albert E.,Guzek, Donald B.,Hintz, Michael A.,McCormick, Ellen L.,Scully, Douglas A.,Siderewicz, Joseph M.,Taylor, William J.,Truesdell, Susan J.,Wax, Richard G.. "Biocatalytic oxidation of 2-methylquinoxaline to 2-quinoxalinecarboxylic acid". . p. 477 - 481. Retrieved 2002.
• 2、 Li, Zongyang,Zhang, Jiaheng,Li, Yubo,Gao, Haixiang. "Combined theoretical and experimental study on the molecular structure, FT-IR, and NMR spectra of cyadox and 1,4-bisdesoxycyadox". . p. 69 - 75. Retrieved 2013.
• 3、 Desai, Vidya,Desai, Sulaksha,Gaonkar, Sonia Naik,Palyekar, Uddesh,Joshi, Shrinivas D.,Dixit, Sheshagiri K.. "Novel quinoxalinyl chalcone hybrid scaffolds as enoyl ACP reductase inhibitors: Synthesis, molecular docking and biological evaluation". . p. 2174 - 2180. Retrieved 2017.
• 4、 Zhang, Xin-Ke,Miao, Xiao-Yu,Zhou, Yu,Wang, Yu-Mei,Song, Ying-Chun,Liu, Hang,Xiong, Yi-Lu,Li, Ling-Yu,Wu, An-Xin,Zhu, Yan-Ping. "Iodine-catalyzed oxidative annulation: Facile synthesis of pyrazolooxepinopyrazolones: Via methyl azaarene sp3C-H functionalization". supporting information. p. 1236 - 1242. Retrieved 2022/02/19.
• 5、 Xu, Zhengbao,Zhang, Lizhi. "Methanol as a formylating agent in nitrogen heterocycles". . p. 9476 - 9482. Retrieved 2021/11/17.