(1R,3aS,3bR,7aS,8aR,8bR,8cR,10aS)-1-acetyl-5-fluoro-8b,10a-dimethyl-7-oxo-1,2,3,3a,3b,7,7a,8,8a,8b,8c,9,10,10a-tetradecahydrocyclopenta[a]cyclopropa[g]phenanthren-1-yl acetate

Base Information

Chemical Name:(1R,3aS,3bR,7aS,8aR,8bR,8cR,10aS)-1-acetyl-5-fluoro-8b,10a-dimethyl-7-oxo-1,2,3,3a,3b,7,7a,8,8a,8b,8c,9,10,10a-tetradecahydrocyclopenta[a]cyclopropa[g]phenanthren-1-yl acetate
CAS No.:34542-22-8
Molecular Formula:C₂₄H₂₉FO₄
Molecular Weight:400.49
Hs Code.:

(1R,3aS,3bR,7aS,8aR,8bR,8cR,10aS)-1-acetyl-5-fluoro-8b,10a-dimethyl-7-oxo-1,2,3,3a,3b,7,7a,8,8a,8b,8c,9,10,10a-tetradecahydrocyclopenta[a]cyclopropa[g]phenanthren-1-yl acetate

Synonyms:

Suppliers and Price of (1R,3aS,3bR,7aS,8aR,8bR,8cR,10aS)-1-acetyl-5-fluoro-8b,10a-dimethyl-7-oxo-1,2,3,3a,3b,7,7a,8,8a,8b,8c,9,10,10a-tetradecahydrocyclopenta[a]cyclopropa[g]phenanthren-1-yl acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,3aS,3bR,7aS,8aR,8bR,8cR,10aS)-1-acetyl-5-fluoro-8b,10a-dimethyl-7-oxo-1,2,3,3a,3b,7,7a,8,8a,8b,8c,9,10,10a-tetradecahydrocyclopenta[a]cyclopropa[g]phenanthren-1-yl acetate

Chemical Property:

Vapor Pressure:3.06E-10mmHg at 25°C
Boiling Point:502.8°Cat760mmHg
Flash Point:248.5°C
PSA：60.44000
Density:1.24g/cm³
LogP:4.33830

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (1R,3aS,3bR,7aS,8aR,8bR,8cR,10aS)-1-acetyl-5-fluoro-8b,10a-dimethyl-7-oxo-1,2,3,3a,3b,7,7a,8,8a,8b,8c,9,10,10a-tetradecahydrocyclopenta[a]cyclopropa[g]phenanthren-1-yl acetate

There total 6 articles about (1R,3aS,3bR,7aS,8aR,8bR,8cR,10aS)-1-acetyl-5-fluoro-8b,10a-dimethyl-7-oxo-1,2,3,3a,3b,7,7a,8,8a,8b,8c,9,10,10a-tetradecahydrocyclopenta[a]cyclopropa[g]phenanthren-1-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Acetic acid (1R,2S,8R,9R,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-3-oxo-1,2,3,8,9,10,11,12,13,14,15,16,17,20-tetradecahydro-cyclopropa[1,2]cyclopenta[a]phenanthren-17-yl ester

: 34542-22-8
Acetic acid (1R,2S,8R,9R,10R,13S,14S,17R)-17-acetyl-6-fluoro-10,13-dimethyl-3-oxo-1,2,3,8,9,10,11,12,13,14,15,16,17,20-tetradecahydro-cyclopropa[1,2]cyclopenta[a]phenanthren-17-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd-CaCO₃ / toluene

2: TsOH / benzene

3: (i) FClO₃, KOAc, aq. acetone, (ii) HC(OEt)3, TsOH, dioxane, (iii) MnO₂, aq. AcOH

With hydrogen; toluene-4-sulfonic acid; Lindlar's catalyst; In toluene; benzene;
DOI:10.1021/jm00282a022

Reference yield:

: 34554-33-1
Acetic acid (1R,2S,8R,9R,10R,13S,14S,17R)-17-acetyl-10,13-dimethyl-3-oxo-1,2,3,6,7,8,9,10,11,12,13,14,15,16,17,20-hexadecahydro-cyclopropa[1,2]cyclopenta[a]phenanthren-17-yl ester

: 34542-22-8
Acetic acid (1R,2S,8R,9R,10R,13S,14S,17R)-17-acetyl-6-fluoro-10,13-dimethyl-3-oxo-1,2,3,8,9,10,11,12,13,14,15,16,17,20-tetradecahydro-cyclopropa[1,2]cyclopenta[a]phenanthren-17-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: TsOH / benzene

2: (i) FClO₃, KOAc, aq. acetone, (ii) HC(OEt)3, TsOH, dioxane, (iii) MnO₂, aq. AcOH

With toluene-4-sulfonic acid; In benzene;
DOI:10.1021/jm00282a022

Reference yield:

: 34554-34-2
Acetic acid (1R,2S,8R,9R,10R,13S,14S,17R)-17-acetoxy-17-acetyl-10,13-dimethyl-1,2,7,8,9,10,11,12,13,14,15,16,17,20-tetradecahydro-cyclopropa[1,2]cyclopenta[a]phenanthren-3-yl ester

: 34542-22-8
Acetic acid (1R,2S,8R,9R,10R,13S,14S,17R)-17-acetyl-6-fluoro-10,13-dimethyl-3-oxo-1,2,3,8,9,10,11,12,13,14,15,16,17,20-tetradecahydro-cyclopropa[1,2]cyclopenta[a]phenanthren-17-yl ester

Guidance literature:: Multistep reaction; (i) FClO₃, KOAc, aq. acetone, (ii) HC(OEt)3, TsOH, dioxane, (iii) MnO₂, aq. AcOH;
DOI:10.1021/jm00282a022