1-acetyl-5-broMo-2,3-dihydro-1H-indole-7-sulfonyl chloride

Base Information

• Chemical Name: 1-acetyl-5-broMo-2,3-dihydro-1H-indole-7-sulfonyl chloride
• CAS No.: 30691-46-4
• Molecular Formula: C10H9BrClNO3S
• Molecular Weight: 338.609
• Hs Code.: 2933990090
• Mol file: 30691-46-4.mol

Synonyms:1-acetyl-5-bromo-2,3-dihydro-1h-indole-7-sulfonyl chloride;1-Acetyl-5-bromoindolin-7-sulfochlorid;1-acetyl-5-bromo-2,3-dihydro-indole-7-sulfonyl chloride;1H-Indole-7-sulfonyl chloride,1-acetyl-5-bromo-2,3-dihydro;

Chemical Property of 1-acetyl-5-broMo-2,3-dihydro-1H-indole-7-sulfonyl chloride

Chemical Property:

• PSA: 62.83000
• LogP: 3.43140

Purity/Quality:

98%min ^*data from raw suppliers

1-ACETYL-5-BROMO-2,3-DIHYDRO-1H-INDOLE-7-SULFONYL CHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-acetyl-5-broMo-2,3-dihydro-1H-indole-7-sulfonyl chloride

There total 2 articles about 1-acetyl-5-broMo-2,3-dihydro-1H-indole-7-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

5-bromo-N-acetylindoline (22190-38-1) → 1-acetyl-5-bromo-2,3-dihydro-indole-7-sulfonyl chloride (30691-46-4)

Guidance literature:

With chlorosulfonic acid; at 65 - 70 ℃; for 3h;

DOI:10.1055/s-2004-834888

Reference yield:

→ 1-acetyl-5-bromo-2,3-dihydro-indole-7-sulfonyl chloride (30691-46-4)

Guidance literature:

1-Acetyl-5-bromoindolin, Chlorsulfonsaeure;

DOI:10.1021/je60048a042

Reference yield:

1-acetyl-5-bromo-2,3-dihydro-indole-7-sulfonyl chloride (30691-46-4) → 2-[3-(1-acetyl-5-bromo-2,3-dihydro-1H-indole-7-sulfonyl)-propionylamino]-benzoic acid methyl ester

Guidance literature:

Multi-step reaction with 4 steps

1.1: aq. Na₂SO₃; NaHCO₃ / 0.5 h / 90 °C / pH 9 - 10

1.2: aq. AcOH / 20 °C

2.1: H₂O / 20 °C

3.1: PCl₅ / toluene / Heating

4.1: pyridine / dimethylformamide / 1 h / 55 °C

With pyridine; phosphorus pentachloride; sodium hydrogencarbonate; sodium sulfite; In water; N,N-dimethyl-formamide; toluene;

DOI:10.1055/s-2004-834888

upstream raw materials:

5-bromo-N-acetylindoline

Refernces