Methanol, [(S)-(1,1-dimethylethyl)phenylphosphinyl]-, 4-methylbenzenesulfonate

Base Information

• Chemical Name: Methanol, [(S)-(1,1-dimethylethyl)phenylphosphinyl]-, 4-methylbenzenesulfonate
• CAS No.: 309270-25-5
• Molecular Formula: C18H23O4PS
• Molecular Weight: 366.418
• Mol file: 309270-25-5.mol

Synonyms:

Chemical Property of Methanol, [(S)-(1,1-dimethylethyl)phenylphosphinyl]-, 4-methylbenzenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanol, [(S)-(1,1-dimethylethyl)phenylphosphinyl]-, 4-methylbenzenesulfonate

There total 3 articles about Methanol, [(S)-(1,1-dimethylethyl)phenylphosphinyl]-, 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

p-toluenesulfonyl chloride (98-59-9) + (Sp)-tert-butyl(hydroxymethyl)(phenyl)phosphine oxide (249931-33-7) → toluene-4-sulfonic acid tert-butyl-phenyl-phosphinoylmethyl ester (309270-25-5)

Guidance literature:

With trimethylamine hydrochloride; triethylamine; In toluene;

DOI:10.1016/S0040-4039(01)01349-1

Reference yield:

ethyl Phenylphosphinate (172487-18-2,2511-09-3) → toluene-4-sulfonic acid tert-butyl-phenyl-phosphinoylmethyl ester (309270-25-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 1 h / -78 °C

1.2: 90 percent / tetrahydrofuran / 6 h / -78 °C

2.1: 3 Angstroem molecular sieves / Psudomonas fluorescens lipase / diisopropyl ether / 36 °C

3.1: 90 percent / Et₃N; Me₃N*HCl / toluene

With 3 A molecular sieve; trimethylamine hydrochloride; triethylamine; Psudomonas fluorescens lipase; In tetrahydrofuran; di-isopropyl ether; toluene;

DOI:10.1016/S0040-4039(01)01349-1

Reference yield:

tert-butyl(hydroxymethyl)(phenyl)phosphine oxide (106649-33-6) → toluene-4-sulfonic acid tert-butyl-phenyl-phosphinoylmethyl ester (309270-25-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 3 Angstroem molecular sieves / Psudomonas fluorescens lipase / diisopropyl ether / 36 °C

2: 90 percent / Et₃N; Me₃N*HCl / toluene

With 3 A molecular sieve; trimethylamine hydrochloride; triethylamine; Psudomonas fluorescens lipase; In di-isopropyl ether; toluene;

DOI:10.1016/S0040-4039(01)01349-1

upstream raw materials:

p-toluenesulfonyl chloride

(S_p)-tert-butyl(hydroxymethyl)(phenyl)phosphine oxide

ethyl Phenylphosphinate

tert-butyl(hydroxymethyl)(phenyl)phosphine oxide

Downstream raw materials:

(S)-(-)-tert-butylmethylphenylphosphine oxide