L-Leucine, N-[(phenylmethoxy)carbonyl]-L-threonyl-, methyl ester

Base Information

• Chemical Name: L-Leucine, N-[(phenylmethoxy)carbonyl]-L-threonyl-, methyl ester
• CAS No.: 31025-12-4
• Molecular Formula: C19H28N2O6
• Molecular Weight: 380.441
• Mol file: 31025-12-4.mol

Synonyms:

Chemical Property of L-Leucine, N-[(phenylmethoxy)carbonyl]-L-threonyl-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Leucine, N-[(phenylmethoxy)carbonyl]-L-threonyl-, methyl ester

There total 2 articles about L-Leucine, N-[(phenylmethoxy)carbonyl]-L-threonyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N-benzyloxycarbonyl-L-treonine (19728-63-3) + methyl (L)-leucinate hydrochloride (7517-19-3) → Cbz-L-Thr-L-Leu-OMe (31025-12-4)

Guidance literature:

With Sephadex G-50; triethylamine; bromelain; In ethyl acetate; at 37 ℃; for 7h;

DOI:10.1002/jccs.200300025

Reference yield: 75.0%

(S)-Leu-OMe (2666-93-5) + N-benzyloxycarbonyl-L-treonine (19728-63-3) → Cbz-L-Thr-L-Leu-OMe (31025-12-4)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide;

DOI:10.1021/ja00094a008

Reference yield: 86.0%

Cbz-L-Thr-L-Leu-OMe (31025-12-4) → Z-NH-CO-CO-Leu-OMe (131458-42-9)

Guidance literature:

With ruthenium trichloride; sodium periodate; In tetrachloromethane; water; acetonitrile; for 1.5h; Ambient temperature; pH 3 phosphate buffer;

DOI:10.1021/ja00003a048

upstream raw materials:

N-benzyloxycarbonyl-L-treonine

methyl (L)-leucinate hydrochloride

(S)-Leu-OMe

Downstream raw materials:

Z-Thr-Leu-hydrazide

Z-NH-CO-CO-Leu-OMe

Refernces

• 1、 Ranganathan,Vaish,Shah. "Protein backbone modification by novel C(α)-C side-chain scission". . p. 6545 - 6557. Retrieved 2007/10/02.