5-(4-Methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid

Base Information

Chemical Name:5-(4-Methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid
CAS No.:310451-80-0
Molecular Formula:C₁₅H₁₀F₃N₃O₃
Molecular Weight:337.258
Hs Code.:2933990090
DSSTox Substance ID:DTXSID201131060
Mol file:310451-80-0.mol

Synonyms:310451-80-0;5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid;5-(4-Methoxyphenyl)-7-(trifluoromethyl)pyrazolo-[1,5-a]pyrimidine-2-carboxylic acid;MFCD00292866;SCHEMBL1718174;DTXSID201131060;STK348768;AKOS000304182;CCG-202865;5-(4-Methoxy-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid;LS-03327;CS-0313024;AB00092646-01;5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylicacid

Suppliers and Price of 5-(4-Methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
5-(4-Methoxyphenyl)-7-(trifluoromethyl)pyrazolo-[1,5-a]pyrimidine-2-carboxylic acid
500mg
$ 189.00

Crysdot
5-(4-Methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylicacid 95+%
5g
$ 752.00

AK Scientific
5-(4-Methoxyphenyl)-7-(trifluoromethyl)pyrazolo-[1,5-a]pyrimidine-2-carboxylicacid
500mg
$ 305.00

Total 4 raw suppliers

Chemical Property of 5-(4-Methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid

Chemical Property:

Melting Point:223-225 °C(Solv: acetonitrile (75-05-8))
PKA:-2.98±0.41(Predicted)
PSA：76.72000
Density:1.51±0.1 g/cm3(Predicted)
LogP:3.12190
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:3
Exact Mass:337.06742568
Heavy Atom Count:24
Complexity:469

Purity/Quality:

98%min ^*data from raw suppliers

5-(4-Methoxyphenyl)-7-(trifluoromethyl)pyrazolo-[1,5-a]pyrimidine-2-carboxylic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=NC3=CC(=NN3C(=C2)C(F)(F)F)C(=O)O

Technology Process of 5-(4-Methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid

There total 2 articles about 5-(4-Methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: C₁₇H₁₄F₃N₃O₃

: 310451-80-0
5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid

Guidance literature:: With water; sodium hydroxide; In methanol; at 20 ℃; for 5h;

Reference yield:

: 15191-68-1
4,4,4-trifluoro-1-(4-methoxyphenyl)-1,3-butanedione

: 310451-80-0
5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / 5 h / Reflux

2: sodium hydroxide; water / methanol / 5 h / 20 °C

With water; acetic acid; sodium hydroxide; In methanol;