Methyl(5-methyl-3-indolizinyl) ketone

Base Information

• Chemical Name: Methyl(5-methyl-3-indolizinyl) ketone
• CAS No.: 31108-61-9
• Molecular Formula: C11H11NO
• Molecular Weight: 173.21100
• Mol file: 31108-61-9.mol

Synonyms:3-Acetyl-5-methylindolizin;1-(5-Methyl-indolizin-3-yl)-ethanone;1-(5-Methyl-indolizin-3-yl)-aethanon;

Chemical Property of Methyl(5-methyl-3-indolizinyl) ketone

Chemical Property:

• PSA: 21.48000
• LogP: 2.45030

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl(5-methyl-3-indolizinyl) ketone

There total 4 articles about Methyl(5-methyl-3-indolizinyl) ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-methyl-2-pyridinecarboxaldehyde (1122-72-1) → 3-Acetyl-5-methylindolizin (31108-61-9)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran

2: 450 °C

3: sodium acetate

With tetrahydrofuran; sodium acetate;

DOI:10.1021/ja01515a044

Reference yield:

1-(6-methyl-[2]pyridyl)-allyl alcohol (58457-91-3) → 3-Acetyl-5-methylindolizin (31108-61-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 450 °C

2: sodium acetate

With sodium acetate;

DOI:10.1021/ja01515a044

Reference yield:

1-(5-methyl-indolizin-1-yl)-ethanone (109844-68-0) → 3-Acetyl-5-methylindolizin (31108-61-9)

Guidance literature:

Multi-step reaction with 2 steps

1: concentrated aqueous hydrochloric acid

2: sodium acetate

With hydrogenchloride; sodium acetate;

DOI:10.1021/ja01515a044

upstream raw materials:

5-methyl-indolizine

acetic anhydride

6-methyl-2-pyridinecarboxaldehyde

1-(6-methyl-[2]pyridyl)-allyl alcohol