ethyl 2-(acetylamino)-7-hydroxy-1-benzothiophene-3-carboxylate

Base Information

Chemical Name:ethyl 2-(acetylamino)-7-hydroxy-1-benzothiophene-3-carboxylate
CAS No.:313976-24-8
Molecular Formula:C13H13NO4S
Molecular Weight:279.317
Hs Code.:
Mol file:313976-24-8.mol

Synonyms:2-Acetylamino-7-hydroxy-benzo[b]thiophene-3-carboxylic acid ethyl ester;ethyl 2-(acetylamino)-7-hydroxy-1-benzothiophene-3-carboxylate;

Suppliers and Price of ethyl 2-(acetylamino)-7-hydroxy-1-benzothiophene-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemicals and raw materials
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American Custom Chemicals Corporation
ETHYL 2-(ACETYLAMINO)-7-HYDROXY-1-BENZOTHIOPHENE-3-CARBOXYLATE 95.00%
5MG
$ 502.00

Total 0 raw suppliers

Chemical Property of ethyl 2-(acetylamino)-7-hydroxy-1-benzothiophene-3-carboxylate

Chemical Property:

PSA：103.87000
LogP:2.81500

Purity/Quality:: ETHYL 2-(ACETYLAMINO)-7-HYDROXY-1-BENZOTHIOPHENE-3-CARBOXYLATE 95.00% ^*data from reagent suppliers

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Technology Process of ethyl 2-(acetylamino)-7-hydroxy-1-benzothiophene-3-carboxylate

There total 4 articles about ethyl 2-(acetylamino)-7-hydroxy-1-benzothiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 593-95-3
carbonyl dibromide

: 128811-90-5
ethyl 2-acetamido-6-bromo-7-oxo-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

: 7-bromo-2-(2-bromo-3,4,5-trimethoxyphenyl)-3-isobutyl-6,7-dihydro-3H,5H-benzo[4,5]thieno[2,3-d]pyrimidine-4,8-dione

: 313976-24-8
ethyl 2-acetamido-7-hydroxy-1-benzothiophene-3-carboxylate

Guidance literature:: With hydrogenchloride; Li₂CO₃; lithium bromide; In water; N,N-dimethyl-formamide;

Reference yield: 41.0%

: 128811-90-5
ethyl 2-acetamido-6-bromo-7-oxo-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate

: 313976-24-8
ethyl 2-acetamido-7-hydroxy-1-benzothiophene-3-carboxylate

Guidance literature:: With lithium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 8h;

Reference yield:

: 4506-71-2
ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

: 313976-24-8
ethyl 2-acetamido-7-hydroxy-1-benzothiophene-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid

2: Ce⁽²⁺⁾*2O₄S^(2-); acetic acid / chloroform

3: bromine / chloroform / Reflux

4: lithium carbonate / N,N-dimethyl-formamide / 5 h / 90 °C

With Ce⁽²⁺⁾*2O₄S^(2-); bromine; lithium carbonate; acetic acid; In chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.05.062