3-Pyridinecarboxylic acid, 6-(acetylamino)-1-(2-ethyl-1-oxobutyl)-1,2,5,6-tetrahydro-5-hydroxy-, diphenylmethyl ester, (5S,6S)-

Base Information

Chemical Name:3-Pyridinecarboxylic acid, 6-(acetylamino)-1-(2-ethyl-1-oxobutyl)-1,2,5,6-tetrahydro-5-hydroxy-, diphenylmethyl ester, (5S,6S)-
CAS No.:315700-24-4
Molecular Formula:C27H32N2O5
Molecular Weight:464.561
Hs Code.:

Synonyms:

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Chemical Property of 3-Pyridinecarboxylic acid, 6-(acetylamino)-1-(2-ethyl-1-oxobutyl)-1,2,5,6-tetrahydro-5-hydroxy-, diphenylmethyl ester, (5S,6S)-

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Technology Process of 3-Pyridinecarboxylic acid, 6-(acetylamino)-1-(2-ethyl-1-oxobutyl)-1,2,5,6-tetrahydro-5-hydroxy-, diphenylmethyl ester, (5S,6S)-

There total 4 articles about 3-Pyridinecarboxylic acid, 6-(acetylamino)-1-(2-ethyl-1-oxobutyl)-1,2,5,6-tetrahydro-5-hydroxy-, diphenylmethyl ester, (5S,6S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 908093-98-1
diazodiphenylmethane

: 315700-23-3
(5S,6S)-6-Acetylamino-1-(2-ethyl-butyryl)-5-hydroxy-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid

: 315700-24-4
(5S,6S)-6-Acetylamino-1-(2-ethyl-butyryl)-5-hydroxy-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid benzhydryl ester

Guidance literature:: In methanol; at 20 ℃;
DOI:10.1021/ol000261d

Reference yield:

: siastatin B methyl ester

: 315700-24-4
(5S,6S)-6-Acetylamino-1-(2-ethyl-butyryl)-5-hydroxy-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / benzene

3: sodium hydroxide / methanol; water / 20 °C

4: methanol / 20 °C

With pyridine; sodium hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; water; benzene; 1: Acylation / 2: Dehydration / 3: Hydrolysis / 4: Alkylation;
DOI:10.1021/ol000261d

Reference yield:

: 315700-22-2
(5S,6S)-6-Acetylamino-1-(2-ethyl-butyryl)-5-(2-ethyl-butyryloxy)-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid methyl ester

: 315700-24-4
(5S,6S)-6-Acetylamino-1-(2-ethyl-butyryl)-5-hydroxy-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid benzhydryl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / methanol; water / 20 °C

2: methanol / 20 °C

With sodium hydroxide; In methanol; water; 1: Hydrolysis / 2: Alkylation;
DOI:10.1021/ol000261d