1H-Indole, 1-acetyl-2,3-dimethyl-

Base Information

• Chemical Name: 1H-Indole, 1-acetyl-2,3-dimethyl-
• CAS No.: 31676-43-4
• Molecular Formula: C12H13NO
• Molecular Weight: 187.241
• Mol file: 31676-43-4.mol

Synonyms:1H-Indole,1-acetyl-2,3-dimethyl;N-Acetyl-2,3-dimethyl-indole;1-acetyl-2,3-dimethyl-indole;N-acetyl-2,3-dimethyl-1H-indole;1-Acetyl-2,3-dimethyl-indol;

Chemical Property of 1H-Indole, 1-acetyl-2,3-dimethyl-

Chemical Property:

• PSA: 22.00000
• LogP: 2.91820

Purity/Quality:

99% ^*data from raw suppliers

1-(2,3-dimethyl-1H-indol-1-yl)-Ethanone 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indole, 1-acetyl-2,3-dimethyl-

There total 14 articles about 1H-Indole, 1-acetyl-2,3-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C22H17N3O (1609244-11-2) + C12H13N3O (1609244-12-3) → N-acetyl-2,3-dimethylindole (31676-43-4) + N-benzoyl-2-methyl-3-phenylindole (102451-98-9)

Guidance literature:

With [Rh₂(a,a,a’,a’-tetramethyl-1,3-benzenedipropionic acid)₂]; In toluene; at 130 ℃; for 16h; Inert atmosphere;

DOI:10.1002/anie.201308611

Reference yield: 80.0%

2,3-dimethylindole (91-55-4) + acetic anhydride (108-24-7) → N-acetyl-2,3-dimethylindole (31676-43-4)

Guidance literature:

With camphor-10-sulfonic acid; at 70 ℃;

DOI:10.1016/S0040-4039(98)00633-9

Reference yield: 78.0%

N-(2-(3-oxobutan-2-yl)phenyl)acetamide (14300-16-4) → N-acetyl-2,3-dimethylindole (31676-43-4)

Guidance literature:

With iron(III) chloride; In acetonitrile; at 90 ℃; for 12h; Schlenk technique;

DOI:10.1002/chem.201500272

upstream raw materials:

2,3-dimethylindole

acetic anhydride

acetyl chloride

diethoxy(methyl)carbenium tetrafluoroborate

Downstream raw materials:

N-acetyl-N-(2-acetylphenyl)acetamide

2,3-dimethyl-3-methoxyindolenine

N-acetyl-2-methyl-3-methoxymethylindole

trans N-acetyl-2,3-dimethoxy-2,3-dimethylindoline