10.1039/c8nj00410b
The research focuses on the development and investigation of the catalytic activity of copper nanoparticles (CuNPs) supported on a Zinc oxide-polythiophene (ZnO-PTh) nanocomposite, denoted as CuNPs@ZnO-PTh. The purpose of this study was to create an efficient, cost-effective, and environmentally benign catalyst for the synthesis of propargylamine, tetra-substituted propargylamine, and pyrrolo[1,2-a]quinolines through A3 and KA2 coupling reactions. The researchers used a variety of chemicals in the synthesis process, including zinc chloride, sodium hydroxide, sodium dodecyl sulfate, thiophene, ferric chloride, copper nitrate trihydrate, and hydrazine hydrate. The conclusions drawn from the study highlight the high catalytic performance of the CuNPs@ZnO-PTh catalyst, which was attributed to its high surface area and the synergistic effect of both CuNPs and ZnO-PTh. The catalyst demonstrated excellent activity, selectivity, and recyclability, with the reactions yielding high product yields (up to 98%) in ethylene glycol, a green and biodegradable solvent, under microwave irradiation. The study concludes that this protocol is more efficient and sustainable compared to existing commercial methods.
10.1002/jhet.205
The research focuses on the efficient synthesis of pyrrolo[2,1-a]isoquinolines and pyrrolo[1,2-a]quinolines, which are significant due to their potential applications as central nervous system depressants, calcium entry blockers, and anticancer agents, among others. The study aims to develop a more efficient and environmentally friendly method for synthesizing these compounds by conducting the reactions in aqueous media. The researchers successfully reported a one-pot procedure using quinoline or isoquinoline, phenacylbromide derivatives, and activated alkynes, which resulted in good to excellent yields of the desired heterocyclic compounds. The method offers the advantages of simple operation, mild reaction conditions, high product yields, and cost-effectiveness, demonstrating the potential of water as an efficient promoter in chemical transformations.
