SALOR-INT L157821-1EA

Base Information

• Chemical Name: SALOR-INT L157821-1EA
• CAS No.: 32327-47-2
• Molecular Formula: C10H10N2O2S
• Molecular Weight: 222.26400
• Hs Code.: 2935009090
• DSSTox Substance ID: DTXSID00390610
• Wikidata: Q82187496
• Mol file: 32327-47-2.mol

Synonyms:1-Amino-naphthalin-sulfonamid-5;5-amino-naphthalene-1-sulfonic acid amide;1-Naphthalenesulfonamide,5-amino;5-aminonaphthalene-1-sulphonamide;p-aminonaphthalein sulfonamide;5-Amino-naphthalin-1-sulfonsaeure-amid;

Chemical Property of SALOR-INT L157821-1EA

Chemical Property:

• Melting Point: 259 °C
• Boiling Point: 499.4±37.0 °C(Predicted)
• PKA: 10.28±0.30(Predicted)
• PSA: 94.56000
• Density: 1.435±0.06 g/cm3(Predicted)
• LogP: 3.43170
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 222.04629874
• Heavy Atom Count: 15
• Complexity: 323

Purity/Quality:

97% ^*data from raw suppliers

5-AMINO-1-NAPHTHALENESULFONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=CC=C2S(=O)(=O)N)C(=C1)N

Technology Process of SALOR-INT L157821-1EA

There total 9 articles about SALOR-INT L157821-1EA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C19H26N2O4S (946612-66-4) → 5-amino-1-naphthalene sulfonamide (32327-47-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1039/b701421j

Reference yield: 99.0%

tert-butyl (5-sulfamoylnaphthalen-1-yl)carbamate (1351863-12-1) → 5-amino-1-naphthalene sulfonamide (32327-47-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

DOI:10.1071/CH11297

Reference yield:

1-aminonaphthalene-5-sulfonic acid (84-89-9) → 5-amino-1-naphthalene sulfonamide (32327-47-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / methanol

2: thionylchloride; triphenylphosphine / CH₂Cl₂ / 1.5 h / 20 °C

3: 1.29 g / triethylamine / CH₂Cl₂ / 6 h / 20 °C

4: 99 percent / trifluoroacetic acid / CH₂Cl₂ / 24 h / 20 °C

With thionyl chloride; triethylamine; triphenylphosphine; trifluoroacetic acid; In methanol; dichloromethane;

DOI:10.1039/b701421j

upstream raw materials:

1-Acetylaminonaphthalinsulfonamid-5

C₁₉H₂₆N₂O₄S

1-aminonaphthalene-5-sulfonic acid

(5-chlorosulfonyl-naphthalen-1-yl)-carbamic acid tert-butyl ester