3,4-Difluoro-N-(6-fluoro-3-pyridinyl)benzamide

Base Information

Chemical Name:3,4-Difluoro-N-(6-fluoro-3-pyridinyl)benzamide
CAS No.:325458-00-2
Molecular Formula:C₁₂H₇F₃N₂O
Molecular Weight:252.196
Hs Code.:
DSSTox Substance ID:DTXSID401248350
ChEMBL ID:CHEMBL2046474

Synonyms:CHEMBL2046474;SCHEMBL14339872;DTXSID401248350;BDBM50420042;3,4-Difluoro-N-(6-fluoro-3-pyridinyl)benzamide;325458-00-2

Suppliers and Price of 3,4-Difluoro-N-(6-fluoro-3-pyridinyl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,4-Difluoro-N-(6-fluoro-3-pyridinyl)benzamide

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:252.05104734
Heavy Atom Count:18
Complexity:303

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=C(C=C1C(=O)NC2=CN=C(C=C2)F)F)F

Technology Process of 3,4-Difluoro-N-(6-fluoro-3-pyridinyl)benzamide

There total 3 articles about 3,4-Difluoro-N-(6-fluoro-3-pyridinyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76903-88-3
3,4-difluorobenzoyl chloride

: 1827-27-6
2-fluoro-5-aminopyridine

: 325458-00-2
5,6-difluoro-N-(6-fluoropyridin-3-yl)-nicotinamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/ml200053x

Reference yield:

: 455-86-7
3,4-Difluorobenzoic acid

: 325458-00-2
5,6-difluoro-N-(6-fluoropyridin-3-yl)-nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/ml200053x

Reference yield:

: 456-24-6
2-Fluoro-5-nitropyridine

: 325458-00-2
5,6-difluoro-N-(6-fluoropyridin-3-yl)-nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / dichloromethane

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/ml200053x