5-(2-HYDROXYETHYL)-CYTOSINE

Base Information

• Chemical Name: 5-(2-HYDROXYETHYL)-CYTOSINE
• CAS No.: 89711-99-9
• Molecular Formula: C₆H₉N₃O₂
• Molecular Weight: 155.156
• Hs Code.: 2933599090
• Mol file: 89711-99-9.mol

Synonyms:2(1H)-Pyrimidinone,4-amino-5-(2-hydroxyethyl)- (9CI); Cytosine, 5-(2-hydroxyethyl)- (7CI); NSC528417

Chemical Property of 5-(2-HYDROXYETHYL)-CYTOSINE

Chemical Property:

• PSA: 92.00000
• Density: 1.53g/cm³
• LogP: -0.53190

Purity/Quality:

99% ^*data from raw suppliers

5-(2-HYDROXYETHYL)-CYTOSINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(2-HYDROXYETHYL)-CYTOSINE

There total 2 articles about 5-(2-HYDROXYETHYL)-CYTOSINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-hydroxyethyl-2-thiocytosine (1378801-96-7) → 4-amino-5-(2-hydroxyethyl)-1H-pyrimidin-2-one (89711-99-9)

Guidance literature:

With dihydrogen peroxide; sodium hydroxide;

DOI:10.1080/15257770903109896

Reference yield:

→ 5-Hydroxy-aethyl-cytosin (89711-99-9)

Guidance literature:

5-(2-Acetoxyaethyl)-2-hydroxy-4-mercapto-pyrimidin, NH3-Lsg. in Me. (bei 0grad gesaett.), 100grad, im Rohr, 18h;

DOI:10.1021/jo01032a046

Reference yield: 77.0%

4-amino-5-(2-hydroxyethyl)-1H-pyrimidin-2-one (89711-99-9) → 3,5,6,7-tetrahydro-2H-pyrrolo[2,3-d]pyrimidin-2-one (183202-37-1)

Guidance literature:

4-amino-5-(2-hydroxyethyl)-1H-pyrimidin-2-one; With 1,2-dibromo-1,1,2,2-tetrachloroethane; triphenylphosphine; In N,N-dimethyl-formamide; at 5 - 21 ℃; for 19h;

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 2h; Heating;

DOI:10.1080/15257770903109896

upstream raw materials:

5-hydroxyethyl-2-thiocytosine

Downstream raw materials:

3,5,6,7-tetrahydro-2H-pyrrolo[2,3-d]pyrimidin-2-one

Refernces