Technology Process of Phenol, 4-ethynyl-3-methoxy-, 4-methylbenzenesulfonate
There total 10 articles about Phenol, 4-ethynyl-3-methoxy-, 4-methylbenzenesulfonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
toluene-4-sulfonic acid 3-methoxy-4-trimethylsilanylethynyl-phenyl ester;
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 20 ℃;
for 0.0833333h;
With
water;
In
tetrahydrofuran;
at 20 ℃;
DOI:10.1021/jo0517038
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: K2CO3 / acetone / 21 h / Heating
2.1: 79 percent / K2CO3 / acetone / 3 h / Heating
3.1: 98 percent / PdCl2(PPh3)2; CuI; Et3N / dimethylformamide / 6 h / 100 °C
4.1: tetra-n-butylammonium fluoride / tetrahydrofuran / 0.08 h / 20 °C
4.2: 99 percent / H2O / tetrahydrofuran / 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine;
In
tetrahydrofuran; N,N-dimethyl-formamide; acetone;
3.1: SOnogashira cross-coupling reaction;
DOI:10.1021/jo0517038
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 98 percent / PdCl2(PPh3)2; CuI; Et3N / dimethylformamide / 6 h / 100 °C
2.1: tetra-n-butylammonium fluoride / tetrahydrofuran / 0.08 h / 20 °C
2.2: 99 percent / H2O / tetrahydrofuran / 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine;
In
tetrahydrofuran; N,N-dimethyl-formamide;
1.1: SOnogashira cross-coupling reaction;
DOI:10.1021/jo0517038
