2-(2-Hydroxyethyl)cyclopentan-1-ol

Base Information

• Chemical Name: 2-(2-Hydroxyethyl)cyclopentan-1-ol
• CAS No.: 32943-15-0
• Molecular Formula: C₇H₁₄O₂
• Molecular Weight: 130.187
• DSSTox Substance ID: DTXSID10554802
• Mol file: 32943-15-0.mol

Synonyms:2-(2-Hydroxyethyl)cyclopentan-1-ol;32943-15-0;SCHEMBL7215764;DTXSID10554802;MFCD21924372;AKOS017977547;BS-45137;CS-0161652;D80870;EN300-188745

Chemical Property of 2-(2-Hydroxyethyl)cyclopentan-1-ol

Chemical Property:

• PSA: 40.46000
• LogP: 0.52980
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 130.099379685
• Heavy Atom Count: 9
• Complexity: 83

Purity/Quality:

97% ^*data from raw suppliers

2-(2-Hydroxyethyl)cyclopentan-1-ol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(C(C1)O)CCO

Technology Process of 2-(2-Hydroxyethyl)cyclopentan-1-ol

There total 3 articles about 2-(2-Hydroxyethyl)cyclopentan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (2-oxocyclopentyl)acetate (20826-94-2) → 2-(2-hydroxyethyl)cyclopentanol (32943-15-0) + cis-hexahydro-2H-cyclopenta[b]furan-2-one (10082-36-7) + (±)-trans-ethyl 2-(2-hydroxycyclopentyl)acetate (90647-01-1,94827-49-3)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 - 5 ℃; for 1h; Yield given. Yields of byproduct given;

Reference yield:

ethyl (2-oxocyclopentyl)acetate (20826-94-2) → 2-(2-hydroxyethyl)cyclopentanol (32943-15-0)

Guidance literature:

With sodium tetrahydroborate; In methanol;

DOI:10.1002/anie.201301618

Reference yield:

Tricyclo<9.3.0.04,8>tetradeca-1,8-dien (69618-28-6) → 2-(2-hydroxyethyl)cyclopentanol (32943-15-0)

Guidance literature:

Multistep reaction; (i) O₃, MeOH, Me₂S, (ii) NaBH₄;

DOI:10.1007/BF00925406

upstream raw materials:

Tricyclo<9.3.0.0^4,8>tetradeca-1,8-dien

ethyl (2-oxocyclopentyl)acetate

Downstream raw materials:

7-benzyl-8-oxa-6-aza-spiro[4.5]dec-6-ene

1-<2-Hydroxy-aethyl>-1-phenylacetamino-cyclopentan