L-Leucine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl]-L-leucyl]-, phenylmethyl ester

Base Information

• Chemical Name: L-Leucine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl]-L-leucyl]-, phenylmethyl ester
• CAS No.: 32945-67-8
• Molecular Formula: C30H49N3O6
• Molecular Weight: 547.736
• Mol file: 32945-67-8.mol

Synonyms:

Chemical Property of L-Leucine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl]-L-leucyl]-, phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-Leucine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl]-L-leucyl]-, phenylmethyl ester

There total 11 articles about L-Leucine, N-[N-[N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl]-L-leucyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-4-methyl-pentanoic acid (73401-65-7) + L-Leucine benzyl ester (1738-69-8) → Boc-Leu3-OBzl (32945-67-8)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;

DOI:10.1021/ja710749q

Reference yield: 79.0%

H-Leu2-OBzl (71145-33-0) + N-(tert-butoxycarbonyl)-L-leucine N-carboxyanhydride (125814-33-7) → Boc-Leu3-OBzl (32945-67-8)

Guidance literature:

With sodium hydrogencarbonate; In ethyl acetate; for 0.333333h; Milling; Green chemistry;

DOI:10.1039/c3gc40302e

Reference yield: 65.0%

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) + H-Leu2-OBzl (71145-33-0) → Boc-Leu3-OBzl (32945-67-8)

Guidance literature:

N-tert-butoxycarbonyl-L-leucine; H-Leu₂-OBzl; With sodium dihydrogenphosphate; ethyl cyanoglyoxylate-2-oxime; In ethyl acetate; for 0.0166667h; Inert atmosphere; Milling; Green chemistry;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethyl acetate; for 0.0833333h; Inert atmosphere; Milling; Green chemistry;

DOI:10.1002/ejoc.201600617

upstream raw materials:

N-tert-butoxycarbonyl-L-leucine

L-Leucine benzyl ester

benzyl bromide

2-tert-butoxycarbonylamino-4-methyl-penatnoic acid benzyl ester

Downstream raw materials:

Boc-Ala₂-Leu₃-Pro₂-Leu₃-OBzl

H-Pro₂-Leu₃-OBzl*HCl

Boc-Pro₂-Leu₃-OBzl

Boc-Ala₂-Leu₃-OBzl