7-[3,5-Di-tert-butyl-2-(2,2-difluoroethoxy)phenyl]-3-methyl-2(E),4(E),6(Z)-octatrienoic acid

Base Information

Chemical Name:7-[3,5-Di-tert-butyl-2-(2,2-difluoroethoxy)phenyl]-3-methyl-2(E),4(E),6(Z)-octatrienoic acid
CAS No.:331248-11-4
Molecular Formula:C25H34F2O3
Molecular Weight:
Hs Code.:

Synonyms:

Suppliers and Price of 7-[3,5-Di-tert-butyl-2-(2,2-difluoroethoxy)phenyl]-3-methyl-2(E),4(E),6(Z)-octatrienoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 3 raw suppliers

Chemical Property of 7-[3,5-Di-tert-butyl-2-(2,2-difluoroethoxy)phenyl]-3-methyl-2(E),4(E),6(Z)-octatrienoic acid

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 7-[3,5-Di-tert-butyl-2-(2,2-difluoroethoxy)phenyl]-3-methyl-2(E),4(E),6(Z)-octatrienoic acid

There total 5 articles about 7-[3,5-Di-tert-butyl-2-(2,2-difluoroethoxy)phenyl]-3-methyl-2(E),4(E),6(Z)-octatrienoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: ethyl (6Z)-7-[3,5-di-tert-butyl-2-(2,2-difluoroethoxy)benzene]-3-methylocta-2,4,6-trienoate

: 331248-11-4
LG₁₀₁₅₀₆

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; Heating;
DOI:10.1021/jm020340q

Reference yield:

: 330934-85-5
4-methyl-6,8-di-tert-butylcoumarin

: 331248-11-4
LG₁₀₁₅₀₆

Guidance literature:: Multi-step reaction with 5 steps

1.1: 96 percent / lithium aluminium hydride / diethyl ether / 0 - 20 °C

2.1: 97 percent / Cs₂CO₃ / dimethylformamide / 20 °C

3.1: 95 percent / NMO; tetrapropylammonium perruthenate / CH₂Cl₂

4.1: n-BuLi; DMPU / tetrahydrofuran; hexane / 0.5 h / -78 °C

4.2: 93 percent / tetrahydrofuran; hexane / -78 - 20 °C

5.1: 61 percent / aq. LiOH / methanol; tetrahydrofuran / Heating

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium hydroxide; lithium aluminium tetrahydride; n-butyllithium; N-methyl-2-indolinone; tetrapropylammonium perruthennate; caesium carbonate; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; 4.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/jm020340q

Reference yield:

: 330934-88-8
(Z)-(3,5-di-tert-butyl-2-hydroxyphenyl)but-2-ene-1-ol

: 331248-11-4
LG₁₀₁₅₀₆

Guidance literature:: Multi-step reaction with 4 steps

1.1: 97 percent / Cs₂CO₃ / dimethylformamide / 20 °C

2.1: 95 percent / NMO; tetrapropylammonium perruthenate / CH₂Cl₂

3.1: n-BuLi; DMPU / tetrahydrofuran; hexane / 0.5 h / -78 °C

3.2: 93 percent / tetrahydrofuran; hexane / -78 - 20 °C

4.1: 61 percent / aq. LiOH / methanol; tetrahydrofuran / Heating

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium hydroxide; n-butyllithium; N-methyl-2-indolinone; tetrapropylammonium perruthennate; caesium carbonate; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; 3.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1021/jm020340q