Carbonic acid, 1,1-dimethylethyl 4-iodo-3,5-dimethylphenyl ester

Base Information

Chemical Name:Carbonic acid, 1,1-dimethylethyl 4-iodo-3,5-dimethylphenyl ester
CAS No.:332186-70-6
Molecular Formula:C₁₃H₁₇IO₃
Molecular Weight:348.181
Hs Code.:

Synonyms:Carbonic acid,1,1-dimethylethyl 4-iodo-3,5-dimethylphenyl ester;4-Iodo-3,5-dimethyl-O-tert-butoxycarbonylphenol;

Suppliers and Price of Carbonic acid, 1,1-dimethylethyl 4-iodo-3,5-dimethylphenyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of Carbonic acid, 1,1-dimethylethyl 4-iodo-3,5-dimethylphenyl ester

Chemical Property:

PSA：35.53000
LogP:4.22190

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Carbonic acid, 1,1-dimethylethyl 4-iodo-3,5-dimethylphenyl ester

There total 1 articles about Carbonic acid, 1,1-dimethylethyl 4-iodo-3,5-dimethylphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-68-9,50356-23-5
3,5-Dimethylphenol

: 332186-70-6
4-Iodo-3,5-dimethyl-O-tert-butoxycarbonylphenol

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / KI; KIO₃; HCl / methanol

2: 98 percent / Et₃N; DMAP / H₂O; tetrahydrofuran

With hydrogenchloride; dmap; potassium iodate; triethylamine; potassium iodide; In tetrahydrofuran; methanol; water;
DOI:10.1016/S0960-894X(00)00660-0

Reference yield:

: 332186-70-6
4-Iodo-3,5-dimethyl-O-tert-butoxycarbonylphenol

: 378185-86-5
(2S)-1-[(4S)-4-Benzyl-2-oxo-1,3-oxazolan-3-yl]-3-(4-tert-butoxycarbonyloxy-2,6-dimethylphenyl)-2-methylpropan-1-one

Guidance literature:: Multi-step reaction with 6 steps

1: 61 percent / Pd(OAc)2; Et₃N; (p-MePh)3P / acetonitrile / Heating

2: H₂ / Pd/C / ethyl acetate / 50 °C / 3620.04 Torr

3: 88 percent / 1 N aq. NaOH / tetrahydrofuran

4: Et₃N / diethyl ether / -78 - 0 °C

5: n-BuLi / tetrahydrofuran / -78 - 0 °C

6: 71 percent / NaHMDS / tetrahydrofuran / -78 - -25 °C

With palladium diacetate; sodium hydroxide; n-butyllithium; hydrogen; sodium hexamethyldisilazane; triethylamine; Tri(p-tolyl)phosphine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethyl acetate; acetonitrile; 1: Heck coupling reaction;
DOI:10.1016/S0960-894X(00)00660-0

Reference yield:

: 332186-70-6
4-Iodo-3,5-dimethyl-O-tert-butoxycarbonylphenol

: 263239-05-0
3-(4-tert-Butoxycarbonyloxy-2,6-dimethylphenyl)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 61 percent / Pd(OAc)2; Et₃N; (p-MePh)3P / acetonitrile / Heating

2: H₂ / Pd/C / ethyl acetate / 50 °C / 3620.04 Torr

3: 88 percent / 1 N aq. NaOH / tetrahydrofuran

With palladium diacetate; sodium hydroxide; hydrogen; triethylamine; Tri(p-tolyl)phosphine; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; acetonitrile; 1: Heck coupling reaction;
DOI:10.1016/S0960-894X(00)00660-0