2H-1-Benzopyran-3-ol, 3,4-dihydro-5,7-bis(phenylmethoxy)-2-[3,4,5-tris(phenylmethoxy)phenyl]- , (2S,3R)-

Base Information

Chemical Name:2H-1-Benzopyran-3-ol, 3,4-dihydro-5,7-bis(phenylmethoxy)-2-[3,4,5-tris(phenylmethoxy)phenyl]- , (2S,3R)-
CAS No.:332386-70-6
Molecular Formula:C50H44O7
Molecular Weight:756.895
Hs Code.:

Synonyms:

Suppliers and Price of 2H-1-Benzopyran-3-ol, 3,4-dihydro-5,7-bis(phenylmethoxy)-2-[3,4,5-tris(phenylmethoxy)phenyl]- , (2S,3R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2H-1-Benzopyran-3-ol, 3,4-dihydro-5,7-bis(phenylmethoxy)-2-[3,4,5-tris(phenylmethoxy)phenyl]- , (2S,3R)-

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2H-1-Benzopyran-3-ol, 3,4-dihydro-5,7-bis(phenylmethoxy)-2-[3,4,5-tris(phenylmethoxy)phenyl]- , (2S,3R)-

There total 20 articles about 2H-1-Benzopyran-3-ol, 3,4-dihydro-5,7-bis(phenylmethoxy)-2-[3,4,5-tris(phenylmethoxy)phenyl]- , (2S,3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.2%

: 915954-71-1
[5,7-bis-benzyloxy-2-(3,4,5-tris-benzyloxy-phenyl)-chroman-3-yloxy]-tert-butyl-dimethyl-silane

: 332386-70-6
(+)-(2S,3R)-trans-5,7-bis(benzyloxy)-2-[3,4,5-tris(benzyloxy)phenyl]chroman-3-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 5h;
DOI:10.1246/cl.2006.1006

Reference yield:

: 332386-68-2
(E)-3-[3,4,5-tris(benzyloxy)phenyl]prop-2-en-1-ol

: 332386-70-6
(+)-(2S,3R)-trans-5,7-bis(benzyloxy)-2-[3,4,5-tris(benzyloxy)phenyl]chroman-3-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: 92 percent / K₃Fe(CN)6; MeSO₂NH₂; K₂CO₃ / (DHQD)2-PHAL; K₂OsO₂(OH)2 / 2-methyl-propan-2-ol; H₂O / 40.5 h / 0 °C

2.1: 89 percent / pyridine / 18 h / 0 °C

3.1: 90 percent / K₂CO₃ / methanol; dioxane / 1.5 h / 0 °C

4.1: 93 percent / TMAD; n-Bu₃P / toluene / 10 h / 0 °C

5.1: 93 percent / Li₂NiBr₄ / tetrahydrofuran / 8 h / 0 °C

6.1: 93 percent / 2,6-di-t-butylpyridine / CH₂Cl₂ / 1 h / 0 °C

7.1: tBuLi / tetrahydrofuran / -78 °C

7.2: 53 percent / CH₃OD / tetrahydrofuran / -78 - 0 °C

8.1: 87 percent / TBAF / tetrahydrofuran / 5 h / 0 °C

With pyridine; 2,6-di-tert-butyl-pyridine; tributylphosphine; methanesulfonamide; dilithium tetrabromonickelate(II); diamide; tetrabutyl ammonium fluoride; tert.-butyl lithium; potassium carbonate; potassium hexacyanoferrate(III); K₂OsO₂(OH)2; 1,4-bis(9-O-dihydroquinidine)phthalazine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; toluene; tert-butyl alcohol;
DOI:10.1246/cl.2006.1006

Reference yield:

: (E)-methyl 3-(3,4,5-tris(benzyloxy)phenyl)acrylate

: 332386-70-6
(+)-(2S,3R)-trans-5,7-bis(benzyloxy)-2-[3,4,5-tris(benzyloxy)phenyl]chroman-3-ol

Guidance literature:: Multi-step reaction with 9 steps

1.1: diisobutylaluminum hydride / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 96 percent / aq. Rochelle's salt / tetrahydrofuran; hexane; methanol / 3 h / 0 °C

2.1: 92 percent / K₃Fe(CN)6; MeSO₂NH₂; K₂CO₃ / (DHQD)2-PHAL; K₂OsO₂(OH)2 / 2-methyl-propan-2-ol; H₂O / 40.5 h / 0 °C

3.1: 89 percent / pyridine / 18 h / 0 °C

4.1: 90 percent / K₂CO₃ / methanol; dioxane / 1.5 h / 0 °C

5.1: 93 percent / TMAD; n-Bu₃P / toluene / 10 h / 0 °C

6.1: 93 percent / Li₂NiBr₄ / tetrahydrofuran / 8 h / 0 °C

7.1: 93 percent / 2,6-di-t-butylpyridine / CH₂Cl₂ / 1 h / 0 °C

8.1: tBuLi / tetrahydrofuran / -78 °C

8.2: 53 percent / CH₃OD / tetrahydrofuran / -78 - 0 °C

9.1: 87 percent / TBAF / tetrahydrofuran / 5 h / 0 °C

With pyridine; 2,6-di-tert-butyl-pyridine; tributylphosphine; methanesulfonamide; dilithium tetrabromonickelate(II); diamide; tetrabutyl ammonium fluoride; tert.-butyl lithium; diisobutylaluminium hydride; potassium carbonate; potassium hexacyanoferrate(III); K₂OsO₂(OH)2; 1,4-bis(9-O-dihydroquinidine)phthalazine; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; water; toluene; tert-butyl alcohol;
DOI:10.1246/cl.2006.1006