Ethylene piperidinophosphonite

Base Information

• Chemical Name: Ethylene piperidinophosphonite
• CAS No.: 57842-12-3
• Molecular Formula: C₇H₁₄NO₂P
• Molecular Weight: 175.167
• NSC Number: 202850
• DSSTox Substance ID: DTXSID70206552
• Nikkaji Number: J92.159I
• Wikidata: Q83080382
• Mol file: 57842-12-3.mol

Synonyms:Ethylene piperidinophosphonite;57842-12-3;Piperidinophosphonous acid cyclic ethylene ester;Phosphonous acid, piperidino-, cyclic ethylene ester;BRN 0109075;SCHEMBL5266137;1-Piperidino-2,5-dioxa-2,3,4,5-tetrahydro-1H-phosphole;DTXSID70206552;WLN: T6NTJ A- BT5OPOTJ;NSC202850;NSC 202850;NSC-202850;Phosphonous acid, cyclic ethylene ester;Piperidine,3,2-dioxaphospholan-2-yl)-

Chemical Property of Ethylene piperidinophosphonite

Chemical Property:

• Vapor Pressure: 4.57mmHg at 25°C
• Boiling Point: 146.7°Cat760mmHg
• Flash Point: 42.5°C
• PSA: 35.29000
• Density: g/cm³
• LogP: 1.68390
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 175.07621569
• Heavy Atom Count: 11
• Complexity: 122

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)P2OCCO2

Technology Process of Ethylene piperidinophosphonite

There total 2 articles about Ethylene piperidinophosphonite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperidine (110-89-4) + 2-chloro-1,3,2-dioxaphospholan (822-39-9) → 2-Piperidino-4,5-dihydro-1,3,2-dioxaphosphole (57842-12-3)

Guidance literature:

With diethyl ether; Petroleum ether;

DOI:10.1021/ja01168a032

Reference yield:

→ 2-Piperidino-4,5-dihydro-1,3,2-dioxaphosphole (57842-12-3)

Guidance literature:

/BRN= 506179/, Piperidin;

Reference yield: 78.0%

2-Piperidino-4,5-dihydro-1,3,2-dioxaphosphole (57842-12-3) + 7-Chloro-2-dimethylamino-3-hydroxy-5-phenyl-3H-1,4-benzodiazepine (76458-47-4) → 7-Chloro-2-dimethylamino-5-phenyl-3-piperidinyl-3H-1,4-benzodiazepine (76458-70-3)

Guidance literature:

In toluene; for 4h; Heating;

DOI:10.1002/jhet.5570170504

upstream raw materials:

piperidine

2-chloro-1,3,2-dioxaphospholan

Downstream raw materials:

Ethylen-bis-(diethyldithiocarbamat)

Ethylen-bis-(dibenzyl-dithiocarbamat)

7-Chloro-2-dimethylamino-5-phenyl-3-piperidinyl-3H-1,4-benzodiazepine

7-Chloro-2-ethylamino-5-phenyl-3-piperidinyl-3H-1,4-benzodiazepine