N,4-Dichlorobenzamide

Base Information

• Chemical Name: N,4-Dichlorobenzamide
• CAS No.: 33341-64-9
• Molecular Formula: C7H5Cl2NO
• Molecular Weight: 190.029
• DSSTox Substance ID: DTXSID50500121
• Nikkaji Number: J885.402E
• Mol file: 33341-64-9.mol

Synonyms:N,4-Dichlorobenzamide;33341-64-9;SCHEMBL8606592;DTXSID50500121

Chemical Property of N,4-Dichlorobenzamide

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 188.9748192
• Heavy Atom Count: 11
• Complexity: 143

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C(=O)NCl)Cl

Technology Process of N,4-Dichlorobenzamide

There total 2 articles about N,4-Dichlorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

4-chlorobenzamide (619-56-7) → N-Chloro-4-chlorobenzamide (33341-64-9)

Guidance literature:

With trichloroisocyanuric acid; In methanol; for 1h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b02632

Reference yield:

→ N-Chloro-4-chlorobenzamide (33341-64-9)

Guidance literature:

4-Chlor-benzamid, tert.-Butylhypochlorit in Methanol;

DOI:10.1021/jo01059a099

Reference yield: 82.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + N-Chloro-4-chlorobenzamide (33341-64-9) → (-)-(S)-6-chloro-3-phenyl-3,4-dihydroisoquinolin-1(2H)-one

Guidance literature:

With C₃₄H₃₁CoI₂O₃; silver trifluoromethanesulfonate; cesium pivalate; at 40 ℃; for 18h; enantioselective reaction; Inert atmosphere; Sealed tube; Darkness;

DOI:10.1021/jacs.9b02569

upstream raw materials:

4-chlorobenzamide

Downstream raw materials:

C₁₃H₁₀Cl₃NOSe

3-(4-chloro-phenyl)-7-nitro-2⁽⁴⁾H-benzo[1,2,4]oxadiazine

(4-chloro-benzoyl)-imidosulfurous acid dichloride

C₁₄H₁₀Cl₄N₂O₂Se