6-Methyl-4-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

Base Information

Chemical Name:6-Methyl-4-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid
CAS No.:33448-17-8
Molecular Formula:C₁₂H₁₂O₃
Molecular Weight:204.225
Hs Code.:
DSSTox Substance ID:DTXSID40514151
Nikkaji Number:J1.809.662E

Synonyms:33448-17-8;6-Methyl-4-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid;SCHEMBL9221702;DTXSID40514151;6-Methyl-4-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylicacid

Suppliers and Price of 6-Methyl-4-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 5 raw suppliers

Chemical Property of 6-Methyl-4-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:204.078644241
Heavy Atom Count:15
Complexity:285

Purity/Quality:: ≥99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC2=C(CC(CC2=O)C(=O)O)C=C1

Technology Process of 6-Methyl-4-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

There total 1 articles about 6-Methyl-4-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 2170-03-8
itaconic acid anhydride

: 108-88-3,15644-74-3,16713-13-6
toluene

: 33448-17-8
6-methyl-4-oxo-1,2,3,4-tetrahydro-2-naphthoic acid

: 19340-33-1
2-methylene-4-(4-methylphenyl)-4-oxobutanoic acid

: 22836-96-0
6-methyl-1-oxo-2,3-dihydro-1H-inden-2-ylacetic acid

: 76593-31-2
3-methylene-4-(4-methylphenyl)-4-oxobutanoic acid

Guidance literature:: With aluminium trichloride; In dichloromethane; at 20 ℃; Further Variations:; Solvents; Product distribution;
DOI:10.1248/cpb.50.1407

Reference yield:

: 33448-17-8
6-methyl-4-oxo-1,2,3,4-tetrahydro-2-naphthoic acid

: 101794-65-4
6-methyl-1,2,3,4-tetrahydro-[2]naphthaldehyde-(2,4-dinitro-phenylhydrazone)

Guidance literature:: Multi-step reaction with 3 steps

1: H₂, HClO₄ / Pd-C / acetic acid

2: LiAlH₄

3: (i) CrO₃, acetone, (ii) /BRN= 615586/

With lithium aluminium tetrahydride; perchloric acid; hydrogen; palladium on activated charcoal; In acetic acid;

Reference yield:

: 33448-17-8
6-methyl-4-oxo-1,2,3,4-tetrahydro-2-naphthoic acid

: 101742-95-4
7-Methyl-3-hydroxymethyl-1-phenyl-tetralin

Guidance literature:: Multi-step reaction with 7 steps

1: HCl / benzene / Heating

2: (i) HC(OEt)3, HCl, EtOH, benzene, (ii) LiAlH₄, Et₂O, (iii) aq. HCl

4: NaOMe / methanol; benzene

5: diethyl ether

6: (i) AcOH, H₂SO₄, (ii) KOH, MeOH

7: H₂ / Pd-C / ethanol

With hydrogenchloride; hydrogen; sodium methylate; palladium on activated charcoal; In methanol; diethyl ether; ethanol; benzene;