1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole-3-carbohydrazide

Base Information

• Chemical Name: 1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole-3-carbohydrazide
• CAS No.: 334832-89-2
• Molecular Formula: C10H9ClN4O2
• Molecular Weight: 252.66
• DSSTox Substance ID: DTXSID101328096
• ChEMBL ID: CHEMBL1582314
• Mol file: 334832-89-2.mol

Synonyms:1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole-3-carbohydrazide;1-(4-chlorophenyl)-4-hydroxypyrazole-3-carbohydrazide;334832-89-2;MLS001002384;SMR000369008;CHEMBL1582314;BDBM63850;cid_2114013;DTXSID101328096;HMS1759D20;HMS2748G17;AKOS000117854;CS-0290814;EN300-08007;SR-01000052950;SR-01000052950-1;1-(4-chlorophenyl)-4-hydroxy-3-pyrazolecarbohydrazide;Z55928856;1-(4-chlorophenyl)-4-hydroxy-pyrazole-3-carbohydrazide;1-(4-chlorophenyl)-4-oxidanyl-pyrazole-3-carbohydrazide

Chemical Property of 1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole-3-carbohydrazide

Chemical Property:

• XLogP3: 1.6
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 252.0414032
• Heavy Atom Count: 17
• Complexity: 284

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC=C1N2C=C(C(=N2)C(=O)NN)O)Cl

Technology Process of 1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole-3-carbohydrazide

There total 1 articles about 1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole-3-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

ethyl 4-hydroxy-1-(4-chlorophenyl)-1H-pyrazole-3-carboxylate (26502-56-7) → 1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole-3-carboxylic acid hydrazide (334832-89-2)

Guidance literature:

With hydrazine hydrate; In methanol; for 2h; Heating;

Reference yield: 88.0%

phthalic anhydride (85-44-9) + 1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole-3-carboxylic acid hydrazide (334832-89-2) → N-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole-3-carboxamide (1226775-18-3)

Guidance literature:

In 5,5-dimethyl-1,3-cyclohexadiene; for 12h; Reflux;

DOI:10.1016/j.bmc.2010.02.006

Reference yield: 87.0%

3,4-dimethoxy-benzaldehyde (120-14-9) + 1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole-3-carboxylic acid hydrazide (334832-89-2) → 1-(4-Chloro-phenyl)-4-hydroxy-1H-pyrazole-3-carboxylic acid [1-(3,4-dimethoxy-phenyl)-meth-(E)-ylidene]-hydrazide

Guidance literature:

With sulfuric acid; In ethanol; for 1h; Heating;

upstream raw materials:

ethyl 4-hydroxy-1-(4-chlorophenyl)-1H-pyrazole-3-carboxylate

Downstream raw materials:

1-(1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole-3-carbonyl)-4-phenylthiosemicarbazide