Phosphine oxide, [(2Z)-2-[(3S,5R)-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylene-3-[ (tetrahydro-2H-pyran-2-yl)oxy]cyclohexylidene]ethyl]diphenyl-

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Chemical Name:Phosphine oxide, [(2Z)-2-[(3S,5R)-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylene-3-[ (tetrahydro-2H-pyran-2-yl)oxy]cyclohexylidene]ethyl]diphenyl-
CAS No.:342644-74-0
Molecular Formula:C32H45O4PSi
Molecular Weight:552.766
Hs Code.:

Phosphine oxide,
[(2Z)-2-[(3S,5R)-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylene-3-[
(tetrahydro-2H-pyran-2-yl)oxy]cyclohexylidene]ethyl]diphenyl-

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Chemical Property of Phosphine oxide, [(2Z)-2-[(3S,5R)-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylene-3-[ (tetrahydro-2H-pyran-2-yl)oxy]cyclohexylidene]ethyl]diphenyl-

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Technology Process of Phosphine oxide, [(2Z)-2-[(3S,5R)-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylene-3-[ (tetrahydro-2H-pyran-2-yl)oxy]cyclohexylidene]ethyl]diphenyl-

There total 15 articles about Phosphine oxide, [(2Z)-2-[(3S,5R)-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylene-3-[ (tetrahydro-2H-pyran-2-yl)oxy]cyclohexylidene]ethyl]diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: {2-[(3S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-3-(tetrahydro-pyran-2-yloxy)-cyclohex-(Z)-ylidene]-ethyl}-diphenyl-phosphane

: 342644-74-0
[3S-(1Z,3β,5α)]-[2-[5-(1,1-dimethylethyl)dimethylsilyloxy-3-tetrahydro-pyranyloxy-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide

Guidance literature:: With dihydrogen peroxide; In chloroform; for 0.0166667h;
DOI:10.1021/ja003976k

Reference yield:

: 342644-76-2
(3S,5S)-5,6-epoxy-3-tetrahydropyranyloxy-1-hexene

: 342644-74-0
[3S-(1Z,3β,5α)]-[2-[5-(1,1-dimethylethyl)dimethylsilyloxy-3-tetrahydro-pyranyloxy-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide

Guidance literature:: Multi-step reaction with 11 steps

1.1: MgSO₄ / methanol; H₂O / 12 h / 20 °C

2.1: imidazole / dimethylformamide / 10 h / 20 °C

3.1: DIBAL / CH₂Cl₂; toluene / 1 h / -78 °C

4.1: 12.30 g / NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol / 1 h / 0 °C

5.1: carbonyl diimidazole / tetrahydrofuran / 3 h / 20 °C

5.2: tetrahydrofuran / 24 h / 20 °C

6.1: NaH / tetrahydrofuran; various solvent(s) / 0.5 h / 0 °C

6.2: tetrahydrofuran; various solvent(s) / 12 h / 20 °C

7.1: 13.14 g / DIBAL / toluene; tetrahydrofuran / 2 h / -78 °C

8.1: 57 percent / Pd(OAc)2; PPh₃; Et₃N / dimethylformamide / 6 h / 30 °C

9.1: 2,6-lutidine; LiCl / dimethylformamide / 0.5 h / 0 °C

9.2: 81 percent / methanesulfonyl chloride / dimethylformamide / 2 h / 0 °C

10.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -50 °C

11.1: 1.07 g / aq. H₂O₂ / CHCl₃ / 0.02 h

With 1H-imidazole; 2,6-dimethylpyridine; palladium diacetate; sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; 2-methyl-but-2-ene; dihydrogen peroxide; sodium hydride; diisobutylaluminium hydride; magnesium sulfate; triethylamine; triphenylphosphine; 1,1'-carbonyldiimidazole; lithium chloride; In tetrahydrofuran; methanol; hexane; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; 8.1: Mizoroki-Heck reaction;
DOI:10.1021/ja003976k

Reference yield:

: 342645-63-0
(3R,5S)-3-hydroxy-5-tetrahydropyranyloxy-6-heptenitrile

: 342644-74-0
[3S-(1Z,3β,5α)]-[2-[5-(1,1-dimethylethyl)dimethylsilyloxy-3-tetrahydro-pyranyloxy-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide

Guidance literature:: Multi-step reaction with 10 steps

1.1: imidazole / dimethylformamide / 10 h / 20 °C

2.1: DIBAL / CH₂Cl₂; toluene / 1 h / -78 °C

3.1: 12.30 g / NaClO₂; NaH₂PO₄; 2-methyl-2-butene / 2-methyl-propan-2-ol / 1 h / 0 °C

4.1: carbonyl diimidazole / tetrahydrofuran / 3 h / 20 °C

4.2: tetrahydrofuran / 24 h / 20 °C

5.1: NaH / tetrahydrofuran; various solvent(s) / 0.5 h / 0 °C

5.2: tetrahydrofuran; various solvent(s) / 12 h / 20 °C

6.1: 13.14 g / DIBAL / toluene; tetrahydrofuran / 2 h / -78 °C

7.1: 57 percent / Pd(OAc)2; PPh₃; Et₃N / dimethylformamide / 6 h / 30 °C

8.1: 2,6-lutidine; LiCl / dimethylformamide / 0.5 h / 0 °C

8.2: 81 percent / methanesulfonyl chloride / dimethylformamide / 2 h / 0 °C

9.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -50 °C

10.1: 1.07 g / aq. H₂O₂ / CHCl₃ / 0.02 h

With 1H-imidazole; 2,6-dimethylpyridine; palladium diacetate; sodium chlorite; sodium dihydrogenphosphate; n-butyllithium; 2-methyl-but-2-ene; dihydrogen peroxide; sodium hydride; diisobutylaluminium hydride; triethylamine; triphenylphosphine; 1,1'-carbonyldiimidazole; lithium chloride; In tetrahydrofuran; hexane; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene; tert-butyl alcohol; 7.1: Mizoroki-Heck reaction;
DOI:10.1021/ja003976k