Chemical Property of 1-(2-(5-(2-Methoxyethoxy)benzimidazol-1-yl)quinolin-8-yl)piperidin-4-ylamine
Chemical Property:
- Boiling Point:656.3±65.0 °C(Predicted)
- PKA:9.84±0.20(Predicted)
- PSA：78.43000
- Density:1.32
- LogP:4.29170
- Solubility.:insoluble in H2O; ≥2.39 mg/mL in EtOH with gentle warming and ultrasonic; ≥20.9 mg/mL in DMSO
- XLogP3:3.3
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:6
- Exact Mass:417.21647512
- Heavy Atom Count:31
- Complexity:572
- Purity/Quality:
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99%, *data from raw suppliers
1-[2-[5-(2-Methoxyethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-ylamine *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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Useful:
- Canonical SMILES:COCCOC1=CC2=C(C=C1)N(C=N2)C3=NC4=C(C=CC=C4N5CCC(CC5)N)C=C3
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Uses
CP 673451 is a potent PDGFR-β inhibitor with an IC50 of 1 nM. 1-[2-[5-(2-Methoxyethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-ylamine exhibits antiangiogenic and antitumor properties. It is an inhibitor of platelet-derived growth factor receptor β (PDGFR- β).
