isothiazole-3-carbaldehyde

Base Information

• Chemical Name: isothiazole-3-carbaldehyde
• CAS No.: 34490-97-6
• Molecular Formula: C4H3NOS
• Molecular Weight: 113.14
• Mol file: 34490-97-6.mol

Synonyms:3-formylisothiazole;Isothiazol-3-carboxaldehyd;3-Formylindolizin;3-Formyl-isothiazol;3-INDOLIZINECARBOXALDEHYDE;isothiazole-3-carbaldehyde;

Chemical Property of isothiazole-3-carbaldehyde

Chemical Property:

• Boiling Point: 100.7 °C at 760 mmHg
• Flash Point: 14.7 °C
• PSA: 58.20000
• Density: 1.35 g/cm³
• LogP: 0.95560

Purity/Quality:

99% ^*data from raw suppliers

Isothiazole-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of isothiazole-3-carbaldehyde

There total 2 articles about isothiazole-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-dibromomethyl-isothiazole (56615-21-5) → isothiazole-3-carbaldehyde (34490-97-6)

Guidance literature:

(hydrolysis);

DOI:10.1021/jm00300a043

Reference yield:

→ isothiazole-3-carbaldehyde (34490-97-6)

Guidance literature:

3-Methyl-isothiazol, 1). N-Brom-succinimid, Benzoylperoxid/sied.CCl4 (2 days), 2). AgNO3/wss.A./Δ;

DOI:10.1039/jr9640003114

Reference yield:

p-methoxybenzyl 7β-phenylacetamido-3-chloromethyl-3-cephem-4carboxylate + isothiazole-3-carbaldehyde (34490-97-6) → p-methoxybenzyl 7β-phenylacetamido-3-[2-(isothiazol-3-yl)vinyl]-3-cephem-4-carboxylate

Guidance literature:

With sodium iodide; triphenylphosphine; In N-methyl-acetamide; dichloromethane;

upstream raw materials:

3-dibromomethyl-isothiazole

Refernces