4-Bromo-2-methoxy-6-methylaniline

Base Information

• Chemical Name: 4-Bromo-2-methoxy-6-methylaniline
• CAS No.: 348169-39-1
• Molecular Formula: C8H10BrNO
• Molecular Weight: 216.077
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID40443417
• Nikkaji Number: J2.727.052B
• Wikidata: Q82261216
• Mol file: 348169-39-1.mol

Synonyms:4-bromo-2-methoxy-6-methylaniline;348169-39-1;4-Bromo-2-methyl-6-methoxyaniline;Benzenamine, 4-bromo-2-methoxy-6-methyl-;4-bromo-2-methoxy-6-methyl-aniline;SCHEMBL289511;DTXSID40443417;MTRIPTAVYRAWRG-UHFFFAOYSA-N;2-Methoxy-4-bromo-6-methylaniline;CL8439;MFCD08460263;4-bromo-2-methoxy-6-methylphenylamine;AKOS015999586;AB45704;AM83150;CCG-302715;4-bromo-2-methoxy-6-methyl phenylamine;4-Bromo-2-methoxy-6-methyl-phenylamine;AS-46032;(4-bromo-2-methoxy-6-methyl-phenyl)-amine;EN300-41219;AB01006758-01;A856674

Chemical Property of 4-Bromo-2-methoxy-6-methylaniline

Chemical Property:

• Vapor Pressure: 0.007mmHg at 25°C
• Boiling Point: 271.037oC at 760 mmHg
• PKA: 3.69±0.10(Predicted)
• Flash Point: 117.719oC
• PSA: 35.25000
• Density: 1.458g/cm3
• LogP: 2.92950
• Storage Temp.: 2-8°C
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 214.99458
• Heavy Atom Count: 11
• Complexity: 131

Purity/Quality:

98%min ^*data from raw suppliers

4-Bromo-2-methoxy-6-methylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CC(=C1N)OC)Br

Technology Process of 4-Bromo-2-methoxy-6-methylaniline

There total 2 articles about 4-Bromo-2-methoxy-6-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-methoxy-6-methylbenzeneamine (50868-73-0) → 4-bromo-2-methoxy-6-methyl-phenylamine (348169-39-1)

Guidance literature:

With trimethylbenzylammonium bromide; calcium carbonate; In methanol; dichloromethane; at 20 ℃; for 1h;

Reference yield:

→ 4-bromo-2-methoxy-6-methyl-phenylamine (348169-39-1)

Guidance literature:

Reference yield: 99.0%

2-propenamide (79-06-1,12624-24-7,25038-45-3,27754-57-0,33338-03-3,39387-77-4,68247-81-4,9082-06-8,79079-15-5) + 4-bromo-2-methoxy-6-methyl-phenylamine (348169-39-1) → C11H14N2O2

Guidance literature:

With triethylamine; palladium diacetate; tris-(o-tolyl)phosphine; In acetonitrile; at 70 ℃;

upstream raw materials:

2-methoxy-6-methylbenzeneamine

Downstream raw materials:

3-bromo-5-methoxytoluene

C₈H₈BrN₂O⁽¹⁺⁾*Cl^(1-)

4-[4-(4-bromo-2-methyl-6-methoxyphenylamino)pyrimidin-4-ylamino]benzonitrile

2-fluoro-6-[(3-methyl-5-methoxyphenyl)thio]benzonitrile

Refernces

• 1、 -. "5-[3-[PIPERIDIN-1-YL]-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS 4 AND 5 INHIBITORS FOR TREATING E.G. OSTEOARTHRITIS". Paragraph 0269; 0270. . Retrieved 2018/01/15.
• 2、 Mochizuki, Michiyo,Kori, Masakuni,Kobayashi, Katsumi,Yano, Takahiko,Sako, Yuu,Tanaka, Maiko,Kanzaki, Naoyuki,Gyorkos, Albert C.,Corrette, Christopher P.,Cho, Suk Young,Pratt, Scott A.,Aso, Kazuyoshi. "Design and Synthesis of Benzimidazoles As Novel Corticotropin-Releasing Factor 1 Receptor Antagonists". . p. 2551 - 2566. Retrieved 2016/04/10.