1,2,3,4-Tetrahydroquinoline-8-carboxylic acid

Base Information

• Chemical Name: 1,2,3,4-Tetrahydroquinoline-8-carboxylic acid
• CAS No.: 34849-19-9
• Molecular Formula: C10H11NO2
• Molecular Weight: 177.203
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID20382931
• Wikidata: Q82174414
• Mol file: 34849-19-9.mol

Synonyms:1,2,3,4-Tetrahydroquinoline-8-carboxylic acid;34849-19-9;1,2,3,4-Tetrahydro-8-quinolinecarboxylic acid;1,2,3,4-tetrahydro-quinoline-8-carboxylic acid;SCHEMBL1520555;DTXSID20382931;BBL012935;MFCD01463549;STK790218;AKOS000320307;AM803749;AS-39455;1,2,3,4-Tetrahydroquinoline-8-carboxylic;BB 0261708;CS-0141114;FT-0684116;1,2,3,4-Tetrahydroquinoline-8-carboxylicacid;EN300-376525;A874847

Chemical Property of 1,2,3,4-Tetrahydroquinoline-8-carboxylic acid

Chemical Property:

• Vapor Pressure: 3.67E-06mmHg at 25°C
• Melting Point: 162 °C(Solv: water (7732-18-5); ethanol (64-17-5); cyclohexane (110-82-7))
• Boiling Point: 371oC at 760 mmHg
• PKA: 2.84±0.20(Predicted)
• Flash Point: 178.2oC
• PSA: 49.33000
• Density: 1.223g/cm3
• LogP: 1.88090
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 177.078978594
• Heavy Atom Count: 13
• Complexity: 205

Purity/Quality:

97% ^*data from raw suppliers

1,2,3,4-tetrahydroquinoline-8-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC2=C(C(=CC=C2)C(=O)O)NC1

Technology Process of 1,2,3,4-Tetrahydroquinoline-8-carboxylic acid

There total 4 articles about 1,2,3,4-Tetrahydroquinoline-8-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

8-carboxyquinoline (86-59-9) → 1,2,3,4-tetrahydro-8-quinolinecarboxylic acid (34849-19-9)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethanol; for 2h; under 2585.7 Torr;

DOI:10.1021/jm9603375

Reference yield:

anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → 1,2,3,4-tetrahydro-8-quinolinecarboxylic acid (34849-19-9)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂SO₄; 2-nitro-benzoic acid

2: platinum; ethanol / Hydrogenation

With ethanol; ortho-nitrobenzoic acid; sulfuric acid; platinum;

DOI:10.1021/ja01213a046

Reference yield:

→ 1,2,3,4-tetrahydro-8-quinolinecarboxylic acid (34849-19-9)

Guidance literature:

With hydrogenchloride; tin; at 40 - 50 ℃;

upstream raw materials:

8-carboxyquinoline

anthranilic acid

Downstream raw materials:

ethyl ester of 1,2,3,4-tetrahydroquinoline-8-carboxylic acid

1,2,3,4-tetrahydroisoquinoline