Phospholane, 3-methyl-1-phenyl-, 1-oxide

Base Information

• Chemical Name: Phospholane, 3-methyl-1-phenyl-, 1-oxide
• CAS No.: 34868-22-9
• Molecular Formula: C11H15OP
• Molecular Weight: 194.213
• Mol file: 34868-22-9.mol

Synonyms:Phospholane,3-methyl-1-phenyl-,1-oxide;1-phenyl-3-methylphospholan oxide;3-methyl-1-phenyl-1;3-Methyl-1-phenylphospholane 1-oxide;3-methyl-1-phenylphospholane oxide;3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-phosphole-1-oxide;3-methyl-1-phenylphospholan-1-oxide;3-methyl-P-phenylphospholane oxide;

Chemical Property of Phospholane, 3-methyl-1-phenyl-, 1-oxide

Chemical Property:

• Boiling Point: 359.1±15.0 °C(Predicted)
• PSA: 26.88000
• Density: 1.07±0.1 g/cm3(Predicted)
• LogP: 2.71480

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phospholane, 3-methyl-1-phenyl-, 1-oxide

There total 6 articles about Phospholane, 3-methyl-1-phenyl-, 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-Methyl-1-phenyl-2-phospholene 1-oxide (707-61-9) → 3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-phosphole-1-oxide (34868-22-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; under 15001.5 Torr;

DOI:10.1002/anie.200902525

Reference yield:

2,5-dihydro-3-methyl-1-phenyl-1H-phosphole 1-oxide (7564-51-4) → 3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-phosphole-1-oxide (34868-22-9)

Guidance literature:

With 10% palladium on activated charcoal; hydrogen; In methanol; at 60 ℃; under 9375.94 Torr;

DOI:10.1002/hc.20579

Reference yield:

Tetraphenyldiphosphin (1101-41-3) + 1,4-dibromo-2-methyl-butane (54462-66-7) → 3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-phosphole-1-oxide (34868-22-9)

Guidance literature:

With sodium hydroxide; In 1,2-dichloro-benzene;

upstream raw materials:

3-Methyl-1-phenyl-2-phospholene 1-oxide

Tetraphenyldiphosphin

1,4-dibromo-2-methyl-butane

2,5-dihydro-3-methyl-1-phenyl-1H-phosphole 1-oxide

Downstream raw materials:

3-methyl-1-phenylphospholane

3-methyl-1-phenylphospholane-borane complex

1-(2-methoxy-2-oxoethyl)-3-methyl-1-phenylphospholanium bromide

methyl (2Z)-3-phenylprop-2-enoate

Refernces

• 1、 Nykaza, Trevor V.,Ramirez, Antonio,Harrison, Tyler S.,Luzung, Michael R.,Radosevich, Alexander T.. "Biphilic Organophosphorus-Catalyzed Intramolecular Csp2-H Amination: Evidence for a Nitrenoid in Catalytic Cadogan Cyclizations". supporting information. p. 3103 - 3113. Retrieved 2018/03/08.
• 2、 Nykaza, Trevor V.,Harrison, Tyler S.,Ghosh, Avipsa,Putnik, Rachel A.,Radosevich, Alexander T.. "A Biphilic Phosphetane Catalyzes N-N Bond-Forming Cadogan Heterocyclization via PIII/PV = O Redox Cycling". supporting information. p. 6839 - 6842. Retrieved 2017/05/29.