D-Phenylalanyl-L-valine

Base Information

Chemical Name:D-Phenylalanyl-L-valine
CAS No.:3496-45-5
Molecular Formula:C₁₄H₂₀N₂O₃
Molecular Weight:264.324
Hs Code.:
DSSTox Substance ID:DTXSID80874589
Nikkaji Number:J36.739G
Mol file:3496-45-5.mol

Synonyms:3496-45-5;D-Phenylalanyl-L-valine;N-(D-Phenylalanyl)-L-valine;DTXSID80874589;AKOS011346047

Suppliers and Price of D-Phenylalanyl-L-valine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of D-Phenylalanyl-L-valine

Chemical Property:

PSA：92.42000
LogP:1.87300
XLogP3:-1.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:264.14739250
Heavy Atom Count:19
Complexity:312

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C(C(=O)O)NC(=O)C(CC1=CC=CC=C1)N
Isomeric SMILES:CC(C)[C@@H](C(=O)O)NC(=O)[C@@H](CC1=CC=CC=C1)N

Technology Process of D-Phenylalanyl-L-valine

There total 5 articles about D-Phenylalanyl-L-valine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 112674-78-9,112711-67-8
(S)-3-Methyl-2-[(R)-2-((R)-2-oxo-4-phenyl-oxazolidin-3-yl)-3-phenyl-propionylamino]-butyric acid

: 3496-45-5
(R)-Phe-(S)-Val-OH

Guidance literature:: With lithium; tert-butyl alcohol; In tetrahydrofuran; ammonia; at -78 ℃; for 0.25h;
DOI:10.1016/S0040-4020(01)86038-5

Reference yield:

: 13803-83-3,112674-73-4,130608-02-5,40216-61-3
methyl (S)-2-(benzylideneamino)-3-methylbutanoate

: 3496-45-5
(R)-Phe-(S)-Val-OH

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Et₃N / 1.) CH₂Cl₂, -78 degC, 15 min.; 2.) CH₂Cl₂, allowed to warm to 0 degC (2 h)

2: 1.) 1N NaOH / 2.) 5percent Pd/C / 1.) THF, r.t., 1 h; 2.) MeOH, 50 degC, 5h

3: 97 percent Chromat_. / Li, t-BuOH / liquid ammonia; tetrahydrofuran / 0.25 h / -78 °C

With sodium hydroxide; lithium; triethylamine; tert-butyl alcohol; palladium on activated charcoal; In tetrahydrofuran; ammonia;
DOI:10.1016/S0040-4020(01)86038-5

Reference yield:

: 112674-75-6
(S)-3-Methyl-2-[(3R,4S)-2-oxo-3-((R)-2-oxo-4-phenyl-oxazolidin-3-yl)-4-phenyl-azetidin-1-yl]-butyric acid methyl ester

: 3496-45-5
(R)-Phe-(S)-Val-OH

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 1N NaOH / 2.) 5percent Pd/C / 1.) THF, r.t., 1 h; 2.) MeOH, 50 degC, 5h

2: 97 percent Chromat_. / Li, t-BuOH / liquid ammonia; tetrahydrofuran / 0.25 h / -78 °C

With sodium hydroxide; lithium; tert-butyl alcohol; palladium on activated charcoal; In tetrahydrofuran; ammonia;
DOI:10.1016/S0040-4020(01)86038-5