Technology Process of 4-Morpholinecarboxylic acid,
3-[(4R)-1-[(1,1-dimethylethoxy)carbonyl]-2-[[(1,1-dimethylethoxy)carbon
yl]imino]hexahydro-3-(phenylmethyl)-4-pyrimidinyl]-2-oxo-5,6-diphenyl-,
phenylmethyl ester, (3S,5S,6R)-
There total 6 articles about 4-Morpholinecarboxylic acid,
3-[(4R)-1-[(1,1-dimethylethoxy)carbonyl]-2-[[(1,1-dimethylethoxy)carbon
yl]imino]hexahydro-3-(phenylmethyl)-4-pyrimidinyl]-2-oxo-5,6-diphenyl-,
phenylmethyl ester, (3S,5S,6R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
di-isopropyl azodicarboxylate; triphenylphosphine;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
DOI:10.1016/S0040-4039(01)00487-7
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium bis(trimethylsilyl)amide
1.2: dimethylaluminum chloride
1.3: 60 percent / tetrahydrofuran / 1 h / -78 °C
2.1: 50 percent / mercuric chloride; triethylamine / dimethylformamide
3.1: 91 percent / aq. HF / acetonitrile / 2 h / 20 °C
4.1: 87 percent / DIAD; PPh3 / tetrahydrofuran / 1 h / 20 °C
With
di-isopropyl azodicarboxylate; hydrogen fluoride; triethylamine; triphenylphosphine; mercury dichloride; lithium hexamethyldisilazane;
In
tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
1.3: Mannich reaction;
DOI:10.1016/S0040-4039(01)00487-7
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 98 percent / alumina / CH2Cl2 / 0.42 h / 0 °C
2.1: lithium bis(trimethylsilyl)amide
2.2: dimethylaluminum chloride
2.3: 60 percent / tetrahydrofuran / 1 h / -78 °C
3.1: 50 percent / mercuric chloride; triethylamine / dimethylformamide
4.1: 91 percent / aq. HF / acetonitrile / 2 h / 20 °C
5.1: 87 percent / DIAD; PPh3 / tetrahydrofuran / 1 h / 20 °C
With
aluminum oxide; di-isopropyl azodicarboxylate; hydrogen fluoride; triethylamine; triphenylphosphine; mercury dichloride; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
2.3: Mannich reaction;
DOI:10.1016/S0040-4039(01)00487-7
