Urea, 1-(4,7-dimethoxy-6-(2-morpholinoethoxy)-5-benzofuranyl)-3-methyl-

Base Information

Chemical Name:Urea, 1-(4,7-dimethoxy-6-(2-morpholinoethoxy)-5-benzofuranyl)-3-methyl-
CAS No.:75883-63-5
Molecular Formula:C₁₈H₂₅N₃O₆
Molecular Weight:379.413
Hs Code.:
DSSTox Substance ID:DTXSID50226793
Nikkaji Number:J87.668B
Wikidata:Q83106320
ChEMBL ID:CHEMBL48101

Synonyms:BRN 5163961;Urea, 1-(4,7-dimethoxy-6-(2-morpholinoethoxy)-5-benzofuranyl)-3-methyl-;N-(4,7-Dimethoxy-6-(2-morpholinoethoxy)-5-benzofuranyl)-N'-methylurea;75883-63-5;CHEMBL48101;DTXSID50226793;LS-159896;1-[4,7-Dimethoxy-6-(2-morpholinoethoxy)benzofuran-5-yl]-3-methylurea

Suppliers and Price of Urea, 1-(4,7-dimethoxy-6-(2-morpholinoethoxy)-5-benzofuranyl)-3-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Urea, 1-(4,7-dimethoxy-6-(2-morpholinoethoxy)-5-benzofuranyl)-3-methyl-

Chemical Property:

Vapor Pressure:3.37E-11mmHg at 25°C
Boiling Point:527.1°Cat760mmHg
Flash Point:272.6°C
Density:1.259g/cm³
XLogP3:0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:7
Exact Mass:379.17433553
Heavy Atom Count:27
Complexity:476

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNC(=O)NC1=C(C2=C(C(=C1OCCN3CCOCC3)OC)OC=C2)OC

Technology Process of Urea, 1-(4,7-dimethoxy-6-(2-morpholinoethoxy)-5-benzofuranyl)-3-methyl-

There total 5 articles about Urea, 1-(4,7-dimethoxy-6-(2-morpholinoethoxy)-5-benzofuranyl)-3-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 3240-94-6
N-(2-chlorethyl)morpholine

: 66203-89-2
N-(4,7-dimethoxy-6-hydroxy-5-benzofuranyl)-N'-methylurea

: 75883-63-5
1-[4,7-Dimethoxy-6-(2-morpholin-4-yl-ethoxy)-benzofuran-5-yl]-3-methyl-urea

Guidance literature:: With potassium carbonate; In acetonitrile; for 4h; Heating;
DOI:10.1021/jm00134a007

Reference yield:

: 52631-79-5
N-(4,7-dimethoxy-6-hydroxy-5-benzofuranyl)acetamide

: 75883-63-5
1-[4,7-Dimethoxy-6-(2-morpholin-4-yl-ethoxy)-benzofuran-5-yl]-3-methyl-urea

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / HCl / ethanol / 20 h / Heating

2: 89 percent / CHCl₃ / 2 h / Ambient temperature

3: 63 percent / K₂CO₃ / acetonitrile / 4 h / Heating

With hydrogenchloride; potassium carbonate; In ethanol; chloroform; acetonitrile;
DOI:10.1021/jm00134a007

Reference yield:

: 484-51-5
5-acetyl-6-hydroxy-4,7-dimethoxybenzofuran

: 75883-63-5
1-[4,7-Dimethoxy-6-(2-morpholin-4-yl-ethoxy)-benzofuran-5-yl]-3-methyl-urea

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / hydroxylamine hydrochloride, conc. NaOH / ethanol; H₂O / 6 h / Heating

2: 75 percent / aq. AcOH, HCl(g) / 0.5 h / 90 °C

3: 90 percent / HCl / ethanol / 20 h / Heating

4: 89 percent / CHCl₃ / 2 h / Ambient temperature

5: 63 percent / K₂CO₃ / acetonitrile / 4 h / Heating

With hydrogenchloride; sodium hydroxide; hydroxylamine hydrochloride; potassium carbonate; acetic acid; In ethanol; chloroform; water; acetonitrile;
DOI:10.1021/jm00134a007