2(1H)-Pyrimidinone, 6-amino-5-(4-chlorobenzoyl)-1-methyl-

Base Information

Chemical Name:2(1H)-Pyrimidinone, 6-amino-5-(4-chlorobenzoyl)-1-methyl-
CAS No.:353285-41-3
Molecular Formula:C12H10ClN3O2
Molecular Weight:263.683
Hs Code.:
DSSTox Substance ID:DTXSID00361047
Wikidata:Q82143150
Mol file:353285-41-3.mol

Synonyms:353285-41-3;2(1H)-Pyrimidinone, 6-amino-5-(4-chlorobenzoyl)-1-methyl-;Oprea1_868010;DTXSID00361047

Suppliers and Price of 2(1H)-Pyrimidinone, 6-amino-5-(4-chlorobenzoyl)-1-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2(1H)-Pyrimidinone, 6-amino-5-(4-chlorobenzoyl)-1-methyl-

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:263.0461543
Heavy Atom Count:18
Complexity:437

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C(=C(C=NC1=O)C(=O)C2=CC=C(C=C2)Cl)N

Technology Process of 2(1H)-Pyrimidinone, 6-amino-5-(4-chlorobenzoyl)-1-methyl-

There total 2 articles about 2(1H)-Pyrimidinone, 6-amino-5-(4-chlorobenzoyl)-1-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 2-(4-chlorobenzoyl)-3-(3-methylureido)propenenitrile

: 353285-41-3
4-amino-5-(4-chlorobenzoyl)-3-methyl-2(3H)-pyrimidone

Guidance literature:: With sodium ethanolate; In ethanol; for 1h; Heating;
DOI:10.1007/s00706-004-0192-8

Reference yield:

: 4640-66-8
p-chlorobenzoylacetonitrile

: 353285-41-3
4-amino-5-(4-chlorobenzoyl)-3-methyl-2(3H)-pyrimidone

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / 0.5 h / 60 - 70 °C

2: 56 percent / NaOEt / ethanol / 1 h / Heating

With sodium ethanolate; In ethanol; 1: Knoevenagel condensation;
DOI:10.1007/s00706-004-0192-8