phyllanthine

Base Information

Chemical Name:phyllanthine
CAS No.:20072-02-0
Molecular Formula:C₁₄H₁₇NO₃
Molecular Weight:247.294
Hs Code.:
Mol file:20072-02-0.mol

Synonyms:

Suppliers and Price of phyllanthine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Phyllanthine
25mg
$ 24750.00

Total 4 raw suppliers

Chemical Property of phyllanthine

Chemical Property:

Vapor Pressure:4.37E-09mmHg at 25°C
Melting Point:96-98 °C
Boiling Point:472.2°Cat760mmHg
PKA:7.28±0.40(Predicted)
Flash Point:239.4°C
PSA：38.77000
Density:1.3g/cm³
LogP:0.96780

Purity/Quality:

97% ^*data from raw suppliers

Phyllanthine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of phyllanthine

There total 20 articles about phyllanthine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 261156-98-3
(Diethoxy-phosphoryl)-acetic acid (1S,5R,7R,8R)-5-methoxy-9-oxo-2-aza-tricyclo[6.3.1.0^2,7]dodec-10-en-8-yl ester

: 20072-02-0
phyllanthine

Guidance literature:: With 18-crown-6 ether; potassium carbonate; In toluene; at 0 - 20 ℃;
DOI:10.1002/(SICI)1521-3773(20000103)39

Reference yield:

: 261156-79-0
(E)-3-[(2S,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-acrylonitrile

: 20072-02-0
phyllanthine

Guidance literature:: Multi-step reaction with 16 steps

1: 98 percent / H₂ / Pd/C / ethyl acetate / 12 h / 760.05 Torr

2: 100 percent / TBAF / tetrahydrofuran / 0.5 h / 20 °C

3: 84 percent / Jones reagent / acetone / 0.5 h / 20 °C

4: 78 percent / SmI₂; MeOH / tetrahydrofuran / -78 - 20 °C

5: 91 percent / DIPEA / CH₂Cl₂ / 17 h / 0 - 20 °C

6: 100 percent / p-TsOH*H₂O / benzene / 15 h / Heating

7: Na; naphthalene / 1,2-dimethoxy-ethane / 0.25 h / -78 °C

8: 87 percent / PhIO / CH₂Cl₂ / 3.5 h / 20 °C

9: 84 percent / Yb(OTf)3 / acetonitrile / 0 - 20 °C

10: 85 percent / L-Selectride / tetrahydrofuran / 0.5 h / -78 °C

11: 87 percent / NaH / tetrahydrofuran / 20 °C

12: 78 percent / aq. HCl / 26 h / Heating

13: 58 percent / SeO₂; MsOH / CH₂Cl₂ / 0 - 20 °C

14: 84 percent / NaI; BF₃*Et₂O / acetonitrile / 1.5 h / 0 °C

15: 67 percent / DCC / tetrahydrofuran / 0 - 20 °C

16: 84 percent / K₂CO₃; 18-crown-6 / toluene / 0 - 20 °C

With hydrogenchloride; methanol; selenium(IV) oxide; jones reagent; samarium diiodide; naphthalene; methanesulfonic acid; 18-crown-6 ether; iodosylbenzene; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; hydrogen; sodium; L-Selectride; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; sodium iodide; ytterbium(III) triflate; palladium on activated charcoal; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; ethyl acetate; acetone; toluene; acetonitrile; benzene; 1: Catalytic hydrogenation / 2: desilylation / 3: Oxidation / 4: Cyclization / 5: Condensation / 6: cyclocondensation / 7: Reduction / 8: Oxidation / 9: Cycloaddition / 10: Reduction / 11: Etherification / 12: Hydrolysis / 13: Substitution / 14: Substitution / 15: Esterification / 16: Wadsworth-Horner-Emmons cyclization;
DOI:10.1021/jo000260z

Reference yield:

: 261156-97-2
(1S,5R,7R,8R)-8-Hydroxy-5-methoxy-2-aza-tricyclo[6.3.1.0^2,7]dodec-10-en-9-one

: 20072-02-0
phyllanthine

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / DCC / tetrahydrofuran / 0 - 20 °C

2: 84 percent / K₂CO₃; 18-crown-6 / toluene / 0 - 20 °C

With 18-crown-6 ether; potassium carbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; toluene; 1: Esterification / 2: Wadsworth-Horner-Emmons cyclization;
DOI:10.1021/jo000260z