4-(cyclopropylmethoxy)benzoic acid

Base Information

• Chemical Name: 4-(cyclopropylmethoxy)benzoic acid
• CAS No.: 355391-05-8
• Molecular Formula: C11H12O3
• Molecular Weight: 192.214
• Hs Code.: 2916399090
• Mol file: 355391-05-8.mol

Synonyms:4-cyclopropylmethoxybenzoic acid;

Chemical Property of 4-(cyclopropylmethoxy)benzoic acid

Chemical Property:

• PSA: 46.53000
• LogP: 2.17360

Purity/Quality:

99% ，98% ^*data from raw suppliers

4-(Cyclopropylmethoxy)benzoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(cyclopropylmethoxy)benzoic acid

There total 5 articles about 4-(cyclopropylmethoxy)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl 4-(cyclopropylmethoxy)benzoate → 4-(cyclopropylmethoxy)benzoic acid (355391-05-8)

Guidance literature:

methyl 4-(cyclopropylmethoxy)benzoate; With potassium hydroxide; In methanol; water; at 100 ℃; for 0.75h; under 5250.53 - 9000.9 Torr; Microwave irradiation; Sealed tube;

With hydrogenchloride; In methanol; water; pH=<= 2;

DOI:10.1021/jm400587g

Reference yield: 93.0%

Ethyl 4-hydroxybenzoate (120-47-8) + cyclopropylcarbinyl bromide (7051-34-5) → 4-(cyclopropylmethoxy)benzoic acid (355391-05-8)

Guidance literature:

Ethyl 4-hydroxybenzoate; cyclopropylcarbinyl bromide; With sodium ethanolate; In ethanol; for 3h; Reflux; Large scale;

With sodium hydroxide; In ethanol; water; for 2h; Reflux; Large scale;

DOI:10.1016/j.tet.2014.02.040

Reference yield: 54.0%

1-(cyclopropylmethoxy)-4-methylbenzene → 4-(cyclopropylmethoxy)benzoic acid (355391-05-8)

Guidance literature:

With oxygen; uranyl(VI) acetate dihydrate; acetic acid; In acetone; at 20 ℃; for 36h; under 760.051 Torr; Irradiation; Schlenk technique;

DOI:10.1039/d1gc04042a

upstream raw materials:

methyl 4-hydroxylbenzoate

Ethyl 4-hydroxybenzoate

cyclopropylcarbinyl bromide

Downstream raw materials:

C₂₈H₃₀F₂N₄O₂

C₁₈H₁₉ClN₂O₂

tert-butyl ((2S)-1-(3-((4-(cyclopropylmethoxy)benzoyl)amino)-4-nitrophenoxy)propan-2-yl)carbamate

N-(5-(benzyloxy)-3-bromopyridin-2-yl)-4-(cyclopropylmethoxy)benzamide

Refernces

• 1、 Hu, Lijun,Ren, Qiang,Deng, Liming,Zhou, Zongtao,Cai, Zongyu,Wang, Bin,Li, Zheng. "Design, synthesis, and biological studies of novel 3-benzamidobenzoic acid derivatives as farnesoid X receptor partial agonist". supporting information. . Retrieved 2020/12/25.
• 2、 Sawai, Yasuhiro,Mizuno, Masahiro,Ito, Tatsuya,Yamano, Mitsuhisa. "Synthesis of a stable triformylmethane synthon and its scalable application to 7-acylamino-3-formylquinoline syntheses". . p. 2370 - 2377. Retrieved 2014/04/03.