N-Chloro-N-methylbenzylamine

Base Information

• Chemical Name: N-Chloro-N-methylbenzylamine
• CAS No.: 3555-71-3
• Molecular Formula: C8H10ClN
• Molecular Weight: 155.627
• DSSTox Substance ID: DTXSID90519176
• Nikkaji Number: J240.171A
• Wikidata: Q82382181
• Mol file: 3555-71-3.mol

Synonyms:N-Chloro-N-methylbenzylamine;3555-71-3;SCHEMBL2486993;DTXSID90519176;N-Benzyl-N-methylhypochlorous amide

Chemical Property of N-Chloro-N-methylbenzylamine

Chemical Property:

• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 155.0501770
• Heavy Atom Count: 10
• Complexity: 89.3

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(CC1=CC=CC=C1)Cl

Technology Process of N-Chloro-N-methylbenzylamine

There total 2 articles about N-Chloro-N-methylbenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

benzyl-methyl-amine (103-67-3) → N-benzyl-N-chloromethylamine (3555-71-3)

Guidance literature:

With N-chloro-succinimide; In acetonitrile; at 20 ℃; for 1h; Solvent;

DOI:10.1039/c6ra02744j

Reference yield:

→ N-benzyl-N-chloromethylamine (3555-71-3)

Guidance literature:

Benzylmethylamin , N-Chlorosuccinimid;

DOI:10.1021/ja00507a025

Reference yield: 96.0%

N-benzyl-N-chloromethylamine (3555-71-3) + N-(2-naphthalenecarbonyl)-8-aminoquinoline (444079-13-4) → N-(quinolin-8-yl)-2-N-(N-methylbenzylamino)-3-naphthalenecarboxamide (1531629-18-1)

Guidance literature:

N-(2-naphthalenecarbonyl)-8-aminoquinoline; With iron(III)-acetylacetonate; 1,2-bis[di-(4-fluorophenyl)-phosphino]benzene; phenylmagnesium bromide; In tetrahydrofuran; at 65 ℃; for 0.00833333h; Schlenk technique;

N-benzyl-N-chloromethylamine; In tetrahydrofuran; at 65 ℃; Reagent/catalyst; Schlenk technique;

DOI:10.1021/ja412521k

upstream raw materials:

benzyl-methyl-amine

Downstream raw materials:

Benzyl-(2,2-dichloro-propyl)-methyl-amine

N-benzyl-N-methyl-p-toluenesulfonamide

p-toluenesulfonyl chloride

N-Benzylidenemethylamine