Technology Process of 10-(2-Methylbut-3-en-2-yl)-1,3,14-triazapentacyclo[10.9.0.02,10.04,9.015,20]henicosa-4,6,8,15,17,19-hexaene-13,21-dione
There total 5 articles about 10-(2-Methylbut-3-en-2-yl)-1,3,14-triazapentacyclo[10.9.0.02,10.04,9.015,20]henicosa-4,6,8,15,17,19-hexaene-13,21-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
dichloromethane;
at 25 ℃;
for 30h;
Inert atmosphere;
DOI:10.1021/ja509893s
- Guidance literature:
-
With
AnaPT from Neosartorya fischeri; calcium chloride;
In
water; glycerol;
at 37 ℃;
for 24h;
pH=7.5;
Tris-HCl buffer;
Enzymatic reaction;
DOI:10.1039/b902413a
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / 0.33 h / 0 °C
1.2: 4 h / 0 - 23 °C
2.1: (1s,5s)-9-hexyl-9-borabicyclo[3.3.1]nonane; potassium hexamethylsilazane / tetrahydrofuran; 1,4-dioxane / 0.17 h / 0 °C / Schlenk technique; Glovebox
2.2: 0.67 h / 0.24 °C / Inert atmosphere
2.3: 3 h / 0 °C / Inert atmosphere
3.1: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 30 h / 25 °C / Inert atmosphere
With
n-butyllithium; potassium hexamethylsilazane; triethylamine; (1s,5s)-9-hexyl-9-borabicyclo[3.3.1]nonane; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane;
DOI:10.1021/ja509893s
