Phenol, 2,6-bis[[(2-hydroxyethyl)amino]methyl]-4-methyl-

Base Information

• Chemical Name: Phenol, 2,6-bis[[(2-hydroxyethyl)amino]methyl]-4-methyl-
• CAS No.: 357400-02-3
• Molecular Formula: C13H22N2O3
• Molecular Weight: 254.329
• Mol file: 357400-02-3.mol

Synonyms:

Chemical Property of Phenol, 2,6-bis[[(2-hydroxyethyl)amino]methyl]-4-methyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phenol, 2,6-bis[[(2-hydroxyethyl)amino]methyl]-4-methyl-

There total 4 articles about Phenol, 2,6-bis[[(2-hydroxyethyl)amino]methyl]-4-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-{2-benzyloxy-3-[(2-hydroxy-ethylamino)-methyl]-5-methyl-benzylamino}-ethanol → 2,6-bis-[(2-hydroxy-ethylamino)-methyl]-4-methyl-phenol (357400-02-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 4h; under 1900 Torr;

DOI:10.1016/S0960-894X(01)00168-8

Reference yield:

2,6-bis(hydroxymethyl)-4-methylphenol (91-04-3) → 2,6-bis-[(2-hydroxy-ethylamino)-methyl]-4-methyl-phenol (357400-02-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / K₂CO₃ / acetone / 12 h / Heating

2: 87 percent / (COCl)2; DMSO / CH₂Cl₂ / -78 °C

3: 54 percent / NaBH₃CN; HOAc / methanol

4: 83 percent / H₂ / 10 percent Pd/C / methanol / 4 h / 20 °C / 1900 Torr

With oxalyl dichloride; hydrogen; sodium cyanoborohydride; potassium carbonate; acetic acid; dimethyl sulfoxide; palladium on activated charcoal; In methanol; dichloromethane; acetone; 2: Swern oxidation;

DOI:10.1016/S0960-894X(01)00168-8

Reference yield:

[2-(benzyloxy)-5-methyl-1,3-phenylene]dimethanol (152431-33-9) → 2,6-bis-[(2-hydroxy-ethylamino)-methyl]-4-methyl-phenol (357400-02-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / (COCl)2; DMSO / CH₂Cl₂ / -78 °C

2: 54 percent / NaBH₃CN; HOAc / methanol

3: 83 percent / H₂ / 10 percent Pd/C / methanol / 4 h / 20 °C / 1900 Torr

With oxalyl dichloride; hydrogen; sodium cyanoborohydride; acetic acid; dimethyl sulfoxide; palladium on activated charcoal; In methanol; dichloromethane; 1: Swern oxidation;

DOI:10.1016/S0960-894X(01)00168-8

upstream raw materials:

2,6-bis(hydroxymethyl)-4-methylphenol

[2-(benzyloxy)-5-methyl-1,3-phenylene]dimethanol

5-methyl-2-(phenylmethoxy)-1,3-benzenedicarboxaldehyde