1-[2,3,5,6-Tetrafluoro-4-(trifluoromethyl)phenyl]piperidine

Base Information

Chemical Name:1-[2,3,5,6-Tetrafluoro-4-(trifluoromethyl)phenyl]piperidine
CAS No.:36256-87-8
Molecular Formula:C12H10F7N
Molecular Weight:301.207
Hs Code.:
DSSTox Substance ID:DTXSID50515452
Wikidata:Q82376337
Mol file:36256-87-8.mol

Synonyms:1-[2,3,5,6-Tetrafluoro-4-(trifluoromethyl)phenyl]piperidine;36256-87-8;DTXSID50515452;WRINGWMISXEQLW-UHFFFAOYSA-N

Suppliers and Price of 1-[2,3,5,6-Tetrafluoro-4-(trifluoromethyl)phenyl]piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of 1-[2,3,5,6-Tetrafluoro-4-(trifluoromethyl)phenyl]piperidine

Chemical Property:

XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:1
Exact Mass:301.07014646
Heavy Atom Count:20
Complexity:312

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN(CC1)C2=C(C(=C(C(=C2F)F)C(F)(F)F)F)F

Technology Process of 1-[2,3,5,6-Tetrafluoro-4-(trifluoromethyl)phenyl]piperidine

There total 4 articles about 1-[2,3,5,6-Tetrafluoro-4-(trifluoromethyl)phenyl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 110-89-4
piperidine

: 434-64-0
perfluorotoluene

: 36256-87-8
1-Trifluoromethyl-4-N-piperidino-2,3,5,6-tetrafluorobenzene

Guidance literature:: potassium fluoride; pyrographite; at 20 ℃; for 1h;
DOI:10.1016/S0022-1139(00)81559-6

Reference yield: 91.0%

: 110-89-4
piperidine

: 434-64-0
perfluorotoluene

: 36256-87-8
1-Trifluoromethyl-4-N-piperidino-2,3,5,6-tetrafluorobenzene

: [(κ²-{2,6-iPr₂C₆H₃NCMe}₂CH)Mg(μ-F)]₂

Guidance literature:: With [{(MeCN-2,6-ⁱPr₂C₆H₃)₂CH}Mg(2,2,6,6-tetramethylpiperidine)]; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere; Schlenk technique; Glovebox; Microwave irradiation;
DOI:10.1039/c9cc01670h