4-(dimethylamino)-N-(pyridin-2-ylmethyl)benzamide

Base Information

Chemical Name:4-(dimethylamino)-N-(pyridin-2-ylmethyl)benzamide
CAS No.:362622-68-2
Molecular Formula:C15H17N3O
Molecular Weight:255.319
Hs Code.:
DSSTox Substance ID:DTXSID60354930
Nikkaji Number:J1.654.677A
Wikidata:Q82133434
Mol file:362622-68-2.mol

Synonyms:4-(dimethylamino)-N-(pyridin-2-ylmethyl)benzamide;362622-68-2;CBMicro_027415;Oprea1_394206;DTXSID60354930;STL169331;AKOS000678219;BIM-0027261.P001;4-(dimethylamino)-N-[(pyridin-2-yl)methyl]benzamide;Z30166499

Suppliers and Price of 4-(dimethylamino)-N-(pyridin-2-ylmethyl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(dimethylamino)-N-(pyridin-2-ylmethyl)benzamide

Chemical Property:

PSA：45.23000
LogP:2.46850
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:255.137162174
Heavy Atom Count:19
Complexity:285

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C)C1=CC=C(C=C1)C(=O)NCC2=CC=CC=N2

Technology Process of 4-(dimethylamino)-N-(pyridin-2-ylmethyl)benzamide

There total 3 articles about 4-(dimethylamino)-N-(pyridin-2-ylmethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 3731-51-9
2-(Aminomethyl)pyridine

: 4755-50-4
4-(dimethylamino)benzoyl chloride

: 362622-68-2
4-(N,N-dimethylamino)-N-(pyridin-2-ylmethyl)benzamide

Guidance literature:: 2-(Aminomethyl)pyridine; With triethylamine; In dichloromethane; at 20 ℃; for 0.0833333h; Inert atmosphere;

4-(dimethylamino)benzoyl chloride; In dichloromethane; Inert atmosphere;
DOI:10.1021/acs.joc.9b01890

Reference yield: 62.0%

: 3731-51-9
2-(Aminomethyl)pyridine

: 393809-88-6
4-(dimethylamino)bnezoic acid pentafluorophenyl thioester

: 362622-68-2
4-(N,N-dimethylamino)-N-(pyridin-2-ylmethyl)benzamide

Guidance literature:: With triethylamine; In dichloromethane; for 16h;
DOI:10.1002/1522-2675(20010919)84:9<2439::AID-HLCA2439>3.0.CO;2-S

Reference yield:

: 619-84-1
p-N,N-dimethylaminobenzoic acid

: 362622-68-2
4-(N,N-dimethylamino)-N-(pyridin-2-ylmethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / dicyclohexyl carbodiimide / CH₂Cl₂ / 15 h / 0 - 20 °C

2: 62 percent / Et₃N / CH₂Cl₂ / 16 h

With triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1002/1522-2675(20010919)84:9<2439::AID-HLCA2439>3.0.CO;2-S