1-Piperazinecarboxylic acid, 4-[4-[(8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2- yl)amino]phenyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:1-Piperazinecarboxylic acid, 4-[4-[(8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2- yl)amino]phenyl]-, 1,1-dimethylethyl ester
CAS No.:362656-37-9
Molecular Formula:C28H36N6O3
Molecular Weight:504.632
Hs Code.:
Mol file:362656-37-9.mol

1-Piperazinecarboxylic acid,
4-[4-[(8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-
yl)amino]phenyl]-, 1,1-dimethylethyl ester

Synonyms:

Suppliers and Price of 1-Piperazinecarboxylic acid, 4-[4-[(8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2- yl)amino]phenyl]-, 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-Piperazinecarboxylic acid, 4-[4-[(8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2- yl)amino]phenyl]-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-Piperazinecarboxylic acid, 4-[4-[(8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2- yl)amino]phenyl]-, 1,1-dimethylethyl ester

There total 5 articles about 1-Piperazinecarboxylic acid, 4-[4-[(8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2- yl)amino]phenyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 362656-36-8
8-cyclopentyl-2-methanesulfinyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one

: 170911-92-9
4-(4-aminophenyl)-1-t-butyloxycarbonylpiperazine

: 362656-37-9
4-[4-(8-cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: In dimethyl sulfoxide; at 100 ℃; for 24h;
DOI:10.1021/jm049355+

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 362656-37-9
4-[4-(8-cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-diisopropylethylamine / acetonitrile / 14 h / Heating

2: H₂ / Ra-Ni / tetrahydrofuran / 5 h / 20 °C / 2585.74 Torr

3: 45 percent / dimethylsulfoxide / 24 h / 100 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; Ra-Ni; In tetrahydrofuran; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jm049355+

Reference yield:

: 182618-86-6
tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate

: 362656-37-9
4-[4-(8-cyclopentyl-5-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-ylamino)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Ra-Ni / tetrahydrofuran / 5 h / 20 °C / 2585.74 Torr

2: 45 percent / dimethylsulfoxide / 24 h / 100 °C

With hydrogen; Ra-Ni; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1021/jm049355+