10H-Phenothiazine, 10-[(4-ethynylphenyl)methyl]-

Base Information

• Chemical Name: 10H-Phenothiazine, 10-[(4-ethynylphenyl)methyl]-
• CAS No.: 362682-20-0
• Molecular Formula: C21H15NS
• Molecular Weight: 313.423
• Mol file: 362682-20-0.mol

Synonyms:

Chemical Property of 10H-Phenothiazine, 10-[(4-ethynylphenyl)methyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10H-Phenothiazine, 10-[(4-ethynylphenyl)methyl]-

There total 4 articles about 10H-Phenothiazine, 10-[(4-ethynylphenyl)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N-(4-trimethylsilyl-ethynylbenzyl)-phenothiazine → N-(4-ethynyl-benzyl)phenothiazine (362682-20-0)

Guidance literature:

With methanol; potassium carbonate; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1021/acs.inorgchem.6b01287

Reference yield:

1-bromomethyl-4-iodobenzene (16004-15-2) → N-(4-ethynyl-benzyl)phenothiazine (362682-20-0)

Guidance literature:

Multi-step reaction with 3 steps

1: diisopropylamine; n-butyllithium / tetrahydrofuran / 240 h / 20 °C / Schlenk technique; Inert atmosphere

2: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride / benzene / 96 h / 20 °C

3: potassium carbonate / methanol; tetrahydrofuran / 16 h / 20 °C / Inert atmosphere; Schlenk technique

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; potassium carbonate; triethylamine; diisopropylamine; In tetrahydrofuran; methanol; benzene;

DOI:10.1039/c4dt01682c

Reference yield:

N-(4-iodobenzyl)-phenothiazine → N-(4-ethynyl-benzyl)phenothiazine (362682-20-0)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride / benzene / 96 h / 20 °C

2: potassium carbonate / methanol; tetrahydrofuran / 16 h / 20 °C / Inert atmosphere; Schlenk technique

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; benzene;

DOI:10.1039/c4dt01682c

upstream raw materials:

1-bromomethyl-4-iodobenzene

10H-phenothiazine

Downstream raw materials:

(C₁₂H₈NSCH₂C₆H₄C₂)2Pt(N₂C₁₂H₇C₂C₆H₄NO₂)

[Pt(4'-(4-m-nitrophenyl-phenyl)-2,2':6',2''-terpyridine)(4-ethynylbenzyl-N-phenothiazine)]PF₆

[Pt(4'-(4-p-nitrophenyl-phenyl)-2,2':6',2''-terpyridine)(4-ethynylbenzyl-N-phenothiazine)]PF₆