1,2-Bis(methoxymethoxy)benzene

Base Information

• Chemical Name: 1,2-Bis(methoxymethoxy)benzene
• CAS No.: 3688-89-9
• Molecular Formula: C10H14O4
• Molecular Weight: 198.219
• DSSTox Substance ID: DTXSID50499844
• Wikidata: Q82351014
• Mol file: 3688-89-9.mol

Synonyms:1,2-Bis(methoxymethoxy)benzene;3688-89-9;Benzene, 1,2-bis(methoxymethoxy)-;SCHEMBL3185351;1,2-Bis-methoxymethoxy-benzene;DTXSID50499844;OOHFHWWIDAGLRC-UHFFFAOYSA-N;MFCD28133434;CS-0451755

Chemical Property of 1,2-Bis(methoxymethoxy)benzene

Chemical Property:

• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 198.08920892
• Heavy Atom Count: 14
• Complexity: 124

Purity/Quality:

98%+ ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCOC1=CC=CC=C1OCOC

Technology Process of 1,2-Bis(methoxymethoxy)benzene

There total 2 articles about 1,2-Bis(methoxymethoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

benzene-1,2-diol (120-80-9,19481-10-8,37349-32-9) + chloromethyl methyl ether (107-30-2) → bis-methoxymethylenoxy-1,2 benzene (3688-89-9)

Guidance literature:

benzene-1,2-diol; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 1h;

chloromethyl methyl ether; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 18h; Further stages.;

DOI:10.1002/ejoc.200700613

Reference yield:

chloromethyl methyl ether (107-30-2) → bis-methoxymethylenoxy-1,2 benzene (3688-89-9)

Guidance literature:

With ethanol;

Reference yield: 96.0%

bis-methoxymethylenoxy-1,2 benzene (3688-89-9) → 1-chloro-2,3-di(methoxymethoxy)benzene (70461-30-2)

Guidance literature:

bis-methoxymethylenoxy-1,2 benzene; With sec.-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

With hexachloroethane; In tetrahydrofuran; hexane; at -78 - 20 ℃; Further stages.;

DOI:10.1021/jo062543i

upstream raw materials:

benzene-1,2-diol

chloromethyl methyl ether

Downstream raw materials:

2,3-bis-methoxymethoxy-phenethyl alcohol

(bis-methoxymethylenoxy-2',3' phenyl)-1 cyclohexene-2 ol-1

3-acetoxy-1,2-bis(methoxymethoxy)benzene

2,2',3,3'-tetrakis(methoxymethoxy)-1,1'-biphenyl