1-{2-[(4-Methoxybenzyl)oxy]phenyl}ethanone

Base Information

• Chemical Name: 1-{2-[(4-Methoxybenzyl)oxy]phenyl}ethanone
• CAS No.: 371258-91-2
• Molecular Formula: C16H16O3
• Molecular Weight: 256.301
• DSSTox Substance ID: DTXSID80432562
• Nikkaji Number: J1.558.329K
• Mol file: 371258-91-2.mol

Synonyms:1-[2-[(4-methoxyphenyl)methoxy]phenyl]ethanone;1-{2-[(4-methoxybenzyl)oxy]phenyl}ethanone;371258-91-2;Ethanone, 1-[2-[(4-methoxyphenyl)methoxy]phenyl]-;SCHEMBL4938231;DTXSID80432562;DQUMVRSTGOLXHO-UHFFFAOYSA-N;2'-(4-Methoxybenzyloxy)acetophenone;AKOS000180550;A1-05667

Chemical Property of 1-{2-[(4-Methoxybenzyl)oxy]phenyl}ethanone

Chemical Property:

• PSA: 35.53000
• LogP: 3.47680
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 256.109944368
• Heavy Atom Count: 19
• Complexity: 282

Purity/Quality:

1-[2-[(4-Methoxyphenyl)methoxy]phenyl]ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=CC=CC=C1OCC2=CC=C(C=C2)OC

Technology Process of 1-{2-[(4-Methoxybenzyl)oxy]phenyl}ethanone

There total 2 articles about 1-{2-[(4-Methoxybenzyl)oxy]phenyl}ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

o-hydroxyacetophenone (118-93-4,104809-67-8) + p-Methoxybenzyl bromide (2746-25-0) → 1-(2-((4-methoxybenzyl)oxy)phenyl)ethanone (371258-91-2)

Guidance literature:

With potassium carbonate; potassium iodide; In acetone; Heating;

DOI:10.1021/ol034806q

Reference yield: 86.0%

o-hydroxyacetophenone (118-93-4,104809-67-8) + p-methoxybenzyl chloride (824-94-2) → 1-(2-((4-methoxybenzyl)oxy)phenyl)ethanone (371258-91-2)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 1h;

DOI:10.1039/c3ra42113a

Reference yield: 90.0%

1-(2-((4-methoxybenzyl)oxy)phenyl)ethanone (371258-91-2) → o-hydroxyacetophenone (118-93-4,104809-67-8)

Guidance literature:

With trichlorophosphate; In 1,2-dichloro-ethane; at 20 ℃; for 0.5h;

DOI:10.1039/c3ra42113a

upstream raw materials:

o-hydroxyacetophenone

p-methoxybenzyl chloride

p-Methoxybenzyl bromide

Downstream raw materials:

1-<2-<(4-Methoxyphenyl)methoxy>phenyl>-2-<(4-methylphenyl)sulphinyl>ethanone

2'-(4-methoxybenzyloxy)acetophenone tosylhydrazone

2-hydroxy-1-[2-(4-methoxybenzyloxy)phenyl]ethanone

1-[2-(4-methoxybenzyloxy)phenyl]-2-methoxymethoxyethanone

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