1H-Indole-2-carbohydroxamic acid

Base Information

• Chemical Name: 1H-Indole-2-carbohydroxamic acid
• CAS No.: 63408-86-6
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.175
• Hs Code.: 2933990090
• Mol file: 63408-86-6.mol

Synonyms:Indole-2-carbohydroxamic acid;1H-INDOLE-2-CARBOXAMIDE,N-HYDROXY;N-Hydroxyindole-2-carboxamide;2-indolehydroxamic acid;indole-2-hydroxamic acid;

Chemical Property of 1H-Indole-2-carbohydroxamic acid

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 68.61000
• Density: 1.429g/cm³
• LogP: 1.86170

Purity/Quality:

99% ^*data from raw suppliers

INDOLE-2-CARBOHYDROXAMIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indole-2-carbohydroxamic acid

There total 4 articles about 1H-Indole-2-carbohydroxamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

Indole-2-carboxylic acid (1477-50-5,1228050-17-6) → N-hydroxy-1H-indole-2-carboxamide (63408-86-6)

Guidance literature:

Indole-2-carboxylic acid; With 4-(Methylamino)pyridine; diisopropyl-carbodiimide; In dichloromethane; at 20 ℃;

With hydroxylamine; In dichloromethane; water; at 20 ℃; Further stages.;

DOI:10.1016/j.tetlet.2007.12.073

Reference yield:

Indole-2-carbonyl chloride (58881-45-1) → N-hydroxy-1H-indole-2-carboxamide (63408-86-6)

Guidance literature:

With hydroxylamine; In diethyl ether; at 20 ℃;

DOI:10.1021/jm501330g

Reference yield:

C14H16N2O3 → N-hydroxy-1H-indole-2-carboxamide (63408-86-6)

Guidance literature:

With hydrogenchloride; In methanol; water; at 20 - 70 ℃;

DOI:10.1002/cmdc.201800238

upstream raw materials:

2-carbethoxyindole

Indole-2-carboxylic acid

Indole-2-carbonyl chloride

Downstream raw materials:

1-(2-Chloro-phenyl)-2-hydroxy-1,4-dihydro-2H-pyrrolo[3,4-b]indol-3-one

2-Hydroxy-1-(2-hydroxy-phenyl)-1,4-dihydro-2H-pyrrolo[3,4-b]indol-3-one

Acetic acid 1-(2-chloro-phenyl)-3-oxo-3,4-dihydro-1H-pyrrolo[3,4-b]indol-2-yl ester

1-phenyl-2-acetoxy-3-keto-1,3-dihydropyrrolo<3,4-b>indole

Refernces

• 1、 Ai, Teng,Xu, Yanli,Qiu, Li,Geraghty, Robert J.,Chen, Liqiang. "Hydroxamic acids block replication of hepatitis c virus". . p. 785 - 800. Retrieved 2015/01/30.
• 2、 Lopez-Arza, V.,Valiente, P.,Jimenez, M.,Sanchez, A.,Rodriguez, J.. "POLAROGRAPHIC BEHAVIOUR OF INDOLE-2-HYDROXAMIC ACID BY DPP". . p. 441 - 444. Retrieved 2007/10/02.