(E)-3-Iodo-2-buten-1-ol

Base Information

• Chemical Name: (E)-3-Iodo-2-buten-1-ol
• CAS No.: 37428-58-3
• Molecular Formula: C4H7IO
• Molecular Weight: 198.00200
• Mol file: 37428-58-3.mol

Synonyms:3-iodo-but-2E-en-1-ol;trans-2-hexenoyl-CoA;Hex-2-trans-enoyl-CoA;trans-D2,3-Hexenoyl-CoA;S-hex-2t-enoyl-coenzyme-A;trans-2-Hexenoylcoenzyme A;hexenoyl-CoA;S-Hex-2t-enoyl-coenzym-A;

Chemical Property of (E)-3-Iodo-2-buten-1-ol

Chemical Property:

• PSA: 20.23000
• LogP: 1.31750
• Storage Temp.: Amber Vial, -20°C Freezer
• Solubility.: Chloroform, Dichloromethane, Ethyl Acetate

Purity/Quality:

98% ^*data from raw suppliers

(E)-3-Iodo-2-buten-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (E)-3-Iodo-2-buten-1-ol (cas# 37428-58-3) is a compound useful in organic synthesis.

Technology Process of (E)-3-Iodo-2-buten-1-ol

There total 4 articles about (E)-3-Iodo-2-buten-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2E)-3-methyl-3-tributylstannylprop-2-en-1-ol (121882-41-5,124607-17-6,850354-34-6) → (E)-β-iodocrotyl alcohol (37428-58-3)

Guidance literature:

With iodine; sodium carbonate; In dichloromethane; at 0 ℃; for 0.166667h;

DOI:10.1039/b500316d

Reference yield: 88.0%

(E)-3-iodobut-2-enoic acid methyl ester (35588-79-5) → (E)-β-iodocrotyl alcohol (37428-58-3)

Guidance literature:

With diisobutylaluminium hydride; In hexane; toluene; at 0 ℃; for 0.5h;

DOI:10.1021/jo00020a027

Reference yield: 49.0%

methyl propargyl alcohol (764-01-2) → (E)-β-iodocrotyl alcohol (37428-58-3)

Guidance literature:

methyl propargyl alcohol; With bis(cyclopentadienyl)titanium dichloride; 2-methylpropylmagnesium chloride; In diethyl ether; at 0 - 20 ℃; for 4h; Inert atmosphere;

With iodine; In diethyl ether; at -78 - 0 ℃; for 1h; Inert atmosphere;

DOI:10.1039/c2ob25100k

upstream raw materials:

(E)-3-iodobut-2-enoic acid methyl ester

methyl propargyl alcohol

ethyl (E)-3-iodomethacrylate

(2E)-3-methyl-3-tributylstannylprop-2-en-1-ol

Downstream raw materials:

((E)-3-Iodo-but-2-ene-1-sulfonyl)-benzene

(E)-tert-butyl((3-iodobut-2-en-1-yl)oxy)dimethylsilane

(E)-tert-butyl(3-iodobut-2-enyloxy)diphenylsilane

1-((E)-3-Iodo-but-2-enyloxymethyl)-4-methoxy-benzene