4-(2-Chloroethyl)-1,1'-biphenyl

Base Information

• Chemical Name: 4-(2-Chloroethyl)-1,1'-biphenyl
• CAS No.: 37729-56-9
• Molecular Formula: C14H13Cl
• Molecular Weight: 216.71
• DSSTox Substance ID: DTXSID10507752
• Wikidata: Q82364146
• Mol file: 37729-56-9.mol

Synonyms:37729-56-9;4-(2-Chloroethyl)-1,1'-biphenyl;SCHEMBL1939987;DTXSID10507752;AKOS014196676

Chemical Property of 4-(2-Chloroethyl)-1,1'-biphenyl

Chemical Property:

• XLogP3: 4.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 3
• Exact Mass: 216.0705781
• Heavy Atom Count: 15
• Complexity: 164

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)CCCl

Technology Process of 4-(2-Chloroethyl)-1,1'-biphenyl

There total 1 articles about 4-(2-Chloroethyl)-1,1'-biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-biphenylboronic acid (5122-94-1) + 1-Bromo-2-chloroethane (107-04-0) → p-vinylbiphenyl (2350-89-2) + 4-(2-chloroethyl)-1,1'-biphenyl (37729-56-9)

Guidance literature:

With 4-methoxypyridine; potassium phosphate; 4,4'-di-tert-butyl-2,2'-bipyridine; nickel dibromide; In 1,2-dimethoxyethane; at 90 ℃; for 24h;

DOI:10.1016/j.tetlet.2019.03.040

Reference yield: 63.0%

4-(2-chloroethyl)-1,1'-biphenyl (37729-56-9) + 5-chloro-2-benzoxazolinone (95-25-0) → 3-(2-([1,1'-biphenyl]-4-yl)ethyl)-5-chlorobenzo[d]oxazol-2(3H)-one

Guidance literature:

5-chloro-2-benzoxazolinone; With potassium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 1h;

4-(2-chloroethyl)-1,1'-biphenyl; In N,N-dimethyl-formamide; at 60 ℃;

DOI:10.1016/j.tetlet.2019.03.040

Reference yield: 61.0%

4-(2-chloroethyl)-1,1'-biphenyl (37729-56-9) → p-vinylbiphenyl (2350-89-2)

Guidance literature:

With sodium hydroxide; In N,N-dimethyl-formamide; at 90 ℃;

DOI:10.1016/j.tetlet.2019.03.040

upstream raw materials:

4-biphenylboronic acid

1-Bromo-2-chloroethane

Downstream raw materials:

3-(4-biphenylyl)propionic acid

4-Phenyl-phenethylhydrazin

p-vinylbiphenyl